November 2011

Tools for studying and using small RNAs: from pathways to functions to therapies

Small RNAs are key regulators of gene expression and genome function, with roles in almost every aspect of biology.

July 2011

Synthetic biology: applications come of age

Synthetic biology was born just over a decade ago, with the goal of applying engineering principles to biological circuitry.

Feburary 2011

Chromatin remodelling and the transcription cycle

In the nucleus, DNA is packaged into chromatin through association with histone proteins and this packaging needs to be modulated to enable genes to be expressed.

January 2011

Applications of zinc finger nucleases

Zinc finger nucleases (ZFNs) are powerful tools for the directed modification of genomic DNA sequences as ZFNs can be designed to target and cleave specific sequences.

October 2010

Regulation of microRNA biogenesis, function and degradation

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are ~21 nucleotides in length and control many developmental and cellular processes in eukaryotes.

November 2009

The pervasive and interleaved transcriptome

Our image of the eukaryotic transcriptome is being transformed.

November 2008

Sequencing technologies — the next generation

DNA sequencing is undergoing a revolution.

December 2005

RNAi and its applications

Double-stranded RNA (dsRNA) molecules can be used to induce a potent silencing process, known as RNA interference (RNAi).

December 2004

Gene map of the extended human major histocompatibility complex

The extended major histocompatibility complex (xMHC) on chromosome 6 is essential for adaptive and innate immunity.

October 2004

From OMICs to systems biology

The field of 'omics' currently polarizes the community of biologists.