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Shinichi Morishita recalls a seminal publication by Weber and Myers, who in 1997 proposed a direct whole-genome shotgun sequencing approach to tackle the human genome.
The Farm Animal GTEx project introduces a new resource for pigs, in which they map genetic variation to differences in gene expression across thousands of samples.
A study in Nature Biotechnology reports a platform that combines lentivirus capabilities with antibody recognition for targeted cell delivery and genome editing.
Beer et al. use multiple complementary approaches to show that declining densities of the Tasmanian devil have had evolutionary effects on gene flow and selection in the subordinate predator, the spotted-tail quoll.
Mashaal Sohail reflects on a 2011 Nature study by Smillie et al., which analysed human microbiome data to show that microbial ecology, rather than phylogeny or geography, is a key driver of horizontal gene transfer.
Two papers in Nature Biotechnology report spatial transcriptomic methods for the simultaneous capture of host and microbial genes to study host–microorganism interactions.
Aashiq Kachroo highlights a recent paper by van Loggerenberg et al. that demonstrates the experimental power of ‘humanized yeast’ to gain insight into the genetic variants underlying disease.
Segun Fatumo highlights a paper by Mahajan et al. that uses a multi-ancestry genome-wide association studies approach to uncover the genetic underpinnings of type 2 diabetes, emphasizing the importance of incorporating diverse populations in such studies.
Geopolitical instability has prompted renewed discussions on the risks of DNA technology being weaponized in international conflict. With today’s changing security environment, the authors argue that risk assessments must be broadened from genetically targeted weapons to a series of new domains.
Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for understanding human disease and the identification of drug targets.
Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially universal process of de novo gene birth and propelled forward this field of research.
Legnini et al. report in Nature Methods their new optogenetic method for controlling gene expression in organoids that can be coupled with single-cell and spatial transcriptomics.
