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  • Series |

    The scale and complexity of genetic and genomic data are ever-expanding, requiring biologists to apply increasingly more sophisticated computational tools in the analysis, interpretation and storage of these data. This series contains articles that focus on the application of these software tools in genetics and genomics.

  • Series |

    Genetics continues to play a crucial part in furthering our understanding of the basis of disease, from revealing biological pathways involved in pathogenesis to improving knowledge of the relative contributions of various genetic and environmental factors. The articles in this series focus on genetic studies of specific diseases or specific processes in pathogenesis.

  • Series |

    The articles in this series discuss insights into chromatin biology and the components and mechanisms of diverse epigenetic processes in health and disease.

  • Series |

    An abundance of data and unprecedented computational power are allowing sophisticated biological models to be devised and tested. This series of articles examines how the coupling of genetics with disciplines such as engineering, statistics, physics and computational biology has enriched our understanding in areas that range from developmental patterning to genetic association analyses.

  • Series |

    The articles in this series consider the range of levels at which transcription is controlled, the molecules involved and how the modes of regulation are adapted to particular types of gene or developmental contexts.

  • Series |

    With improved methods to explore the transcriptome, in recent years there have been great advances in identifying and understanding non-coding RNAs. Regulatory pathways involving small RNAs, such as microRNAs, are now being elucidated in detail, and functions for long non-coding RNAs are also coming to light. The articles in this series discuss insights into the biology of non-coding RNAs of all sizes in a wide range of organisms.

  • Series |

    The articles in this series discuss recent views on regulatory elements, including their role in evolution and the function of chromatin modifications, as well as methods to study these important regions of the genome.

  • Series |

    The articles in this series provide detailed advice on the most appropriate and up-to-date means for designing experiments, with the aim of helping researchers to maximise the value of their data.

  • Series |

    The articles in this series document the many ways in which genetic knowledge is changing medical practice, by facilitating screening tests, by informing diagnoses and drug prescribing and, perhaps before long, by routinely offering personalized health-risk assessments and tailored treatments.

  • Collection |

    Welcome to 'The Epitranscriptome', an article collection from various Nature journals highlighting the role of mRNA modifications in RNA fate and gene expression.

  • Collection |

    Translating the power of high-throughput sequencing technologies from the research sphere into the clinic is a current major focus for many health-care providers and researchers, and the power of these technologies is being harnessed to address an increasingly diverse range of problems. Excitingly, real benefits for patients are starting to emerge in areas from infectious disease and cancer, to common and rare genetic disorders and pre-natal testing. At this critical turning point, this collection highlights the breadth of applications of next-generation sequencing technologies in the clinic and the importance of the insights that are being gained through these methods to improve health.