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The increased availability of reference genomes and the ability to obtain resequencing data in larger quantities are changing the capabilities of crop comparative genomics. Insights into the genetic basis of domestication and agriculturally important traits are emerging, and improved genomic tools have implications for crop breeders and evolutionary biologists.
Studies of the composition, dynamics and function of the human microbiome have taken off in the past two years thanks to the development of new sequencing technologies and advanced algorithms. This article provides a guide to the experimental and analytical best practices in this flourishing field.
This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and non-coding sequences — for the purposes of improving our understanding of basic genome function and disease and discovering effective therapies.