In Brief

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  • A paper in Nature Communications describes a framework for identifying seed traits in food crops that have health-promoting effects on the gut microbiome, with implications for crop improvement approaches.

    • Dorothy Clyde
    In Brief
  • A report in Molecular Cell identifies six new triggers of target-directed miRNA degradation, which are essential for normal Drosophila melanogaster embryogenesis.

    • Dorothy Clyde
    In Brief
  • A new study presents GLUE (graph-linked unified embedding), a generalizable computational framework for integrating unpaired single-cell multi-omics data and for inferring regulatory interactions.

    • Linda Koch
    In Brief
  • A recent study reports the development of Stereo-seq (spatial enhanced resolution omics-sequencing) and its application to generate a spatiotemporal transcriptomic atlas of mouse organogenesis.

    • Linda Koch
    In Brief
  • Gene loss is followed by the rapid emergence of new phenotypes owing to compensatory evolution, finds a recent study using experimental evolution of budding yeast lineages.

    • Linda Koch
    In Brief
  • Levo et al. used quantitative single-cell live imaging to analyse the transcriptional dynamics of fly paralogues separated by long genomic distances, to determine whether they are co-regulated.

    • Linda Koch
    In Brief
  • A paper in Nature Biotechnology describes epigenetic expression inference from cfDNA-sequencing (EPIC-seq), and demonstrates its use for non-invasive classification of cancers.

    • Dorothy Clyde
    In Brief
  • A paper in Molecular Cell reports EpiDamID, a new tool for simultaneously profiling transcription and histone post-translation modifications in single cells.

    • Dorothy Clyde
    In Brief
  • A recent study in Cell describes a developmentally important liquid-to-solid phase transition involving oskar ribonucleoprotein granules in Drosophila melanogaster oocytes.

    • Dorothy Clyde
    In Brief
  • A recent study in Nature Genetics investigates the role of DNA replication in cellular plasticity during mouse embryonic development.

    • Linda Koch
    In Brief
  • Omary et al. map shoot-borne root development at single-cell resolution in tomato to identify the origin of shoot-borne roots.

    • Linda Koch
    In Brief
  • Using whole-genome sequencing and haplotype tracking, Viluma et al. show that the small, highly inbred Scandinavian wolf population has lost substantial genetic diversity over a 30-year period. Their findings have important implications for the management and conservation of endangered species.

    • Dorothy Clyde
    In Brief
  • Flotte et al. describe the first test of adeno-associated virus-based gene therapy for Tay-Sachs disease in humans. Delivery to the thalamus and cerebrospinal fluid was found to be broadly safe, providing a firm basis for future clinical trials.

    • Dorothy Clyde
    In Brief
  • Kong et al. describe 6mASCOPE, a new approach for both quantifying N6-methyldeoxyadenine (6mA) and discriminating its genomic source. Results indicate that eukaryotic genomes contain low levels of 6mA, with bacterial genomes accounting for the majority of 6mA in some samples.

    • Dorothy Clyde
    In Brief
  • A study in eLife identifies 71 nuclear loci associated with mitochondrial DNA copy number (mtDNA-CN) and reveals a putative causal role for mtDNA-CN in dementia.

    • Dorothy Clyde
    In Brief
  • A paper in Cell reports a chromosome-level genome assembly and methylome for the conifer Pinus tabuliformis. At 25.4 Gb, it the largest gymnosperm genome available to date and provides insight into conifer adaptation.

    • Dorothy Clyde
    In Brief
  • A report in Science describes a method to generate transient chimeric antigen receptor (CAR) T cells in vivo via lipid nanoparticle-mediated T cell-targeted delivery of a CAR-encoding nucleoside-modified mRNA.

    • Dorothy Clyde
    In Brief
  • A new method called CIM-seq analyses pairwise co-occurrences of cell types across multiplets to identify cells that are in physical contact with each other in intact tissues.

    • Linda Koch
    In Brief