Research Highlights

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  • Hao et al. present a workflow to integrate single-cell datasets of diverse modalities using a multi-omic dataset as a molecular bridge.

    • Michael Attwaters
    Research Highlight
  • A study in Nature integrates single-cell RNA-sequencing data from more than 1,000 tumour samples to report a pan-cancer atlas of intratumour transcriptional heterogeneity.

    • Kirsty Minton
    Research Highlight
  • A study in Molecular Cell reveals how CTCF and cohesin contribute to genome organization through their roles in forming and stacking chromatin loops.

    • Dorothy Clyde
    Research Highlight
  • Wagner et al. report an organism-wide map of non-coding RNA expression in ageing and rejuvenated mice, identifying a set of broadly deregulated microRNAs that may act as systemic regulators of ageing.

    • Linda Koch
    Research Highlight
  • A new study in Science reports the mechanism through which TDP-43 enables correct processing of STMN2 mRNA, and proposes strategies to restore neuronal Stathmin-2 synthesis in TDP-43 proteinopathies.

    • Linda Koch
    Research Highlight
  • A paper in Cell introduces the EN-TEx resource, a detailed catalogue of allele-specific activity that can be used to develop deep learning models that analyse the biological impact of genetic variants.

    • Linda Koch
    Research Highlight
  • Xu et al. report the development of genetic scores that predict multi-omic traits, enabling cost-effective and powerful analyses for studies that do not include multi-omics data.

    • Linda Koch
    Research Highlight
  • Zhang et al. describe two technologies for the spatially resolved co-mapping of epigenome and transcriptome at near single-cell resolution.

    • Kirsty Minton
    Research Highlight
  • A paper in Science reports that circadian gene expression in humans is affected by sex and age, findings that might explain differential disease prevalence among these groups and have implications for treatment.

    • Dorothy Clyde
    Research Highlight
  • Two studies have revealed that the characteristic distribution of N6-methyladenosine (m6A) — an RNA modification known to be functionally important for mRNA metabolism among other processes — in mRNA is shaped by the exon junction complex during splicing.

    • Dorothy Clyde
    Research Highlight