Research Highlights

Wagner et al. report an organism-wide map of non-coding RNA expression in ageing and rejuvenated mice, identifying a set of broadly deregulated microRNAs that may act as systemic regulators of ageing.

A new study in Nature Genetics describes how changes in the levels of transcription factors can affect normal-range phenotypic variation and disease.

Sen et al. describe the epigenetic changes that underpin aberrant transcription initiation during senescence and ageing.

Arutyunyan et al. describe a spatially resolved, single-cell multi-omics map of the entire maternal–fetal interface in the first trimester of human pregnancy.

A new study in Science reports the mechanism through which TDP-43 enables correct processing of STMN2 mRNA, and proposes strategies to restore neuronal Stathmin-2 synthesis in TDP-43 proteinopathies.

A paper in Cell introduces the EN-TEx resource, a detailed catalogue of allele-specific activity that can be used to develop deep learning models that analyse the biological impact of genetic variants.

Xu et al. report the development of genetic scores that predict multi-omic traits, enabling cost-effective and powerful analyses for studies that do not include multi-omics data.

Zhang et al. describe two technologies for the spatially resolved co-mapping of epigenome and transcriptome at near single-cell resolution.

A new study in Science identifies a role for USB1 in deadenylating microRNAs to regulate blood development.

Two studies analysing ancient hunter-gatherer genomes report detailed insights into the history and interactions of West Eurasian hunter-gatherer groups and highlight the genetic replacement of entire Ice Age populations.

A new study in Cell uses epigenome engineering to confer transgenerational inheritance of DNA methylation states and metabolic traits in mice.

A study in Nature Biotechnology reports a whole-genome sequencing methodology that combines genome and epigenome sequencing in a single run.

A paper in Science reports that circadian gene expression in humans is affected by sex and age, findings that might explain differential disease prevalence among these groups and have implications for treatment.

A collection of articles in Nature describe insights into disease-associated genetic variants obtained from the genetically isolated Finnish population.

Two studies have revealed that the characteristic distribution of N6-methyladenosine (m⁶A) — an RNA modification known to be functionally important for mRNA metabolism among other processes — in mRNA is shaped by the exon junction complex during splicing.

Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals into self-assembling protein filaments.

A study in Nature reports comprehensive, genome-wide mapping of the human methylome that provides mechanistic insights into gene regulation and offers great potential for analysis of cell-free DNA.

Two new studies in Science characterize a CRISPR-associated nuclease–protease system that can be leveraged as a programmable protease-based RNA sensor.

A comparative genomics study published in Nature Communications provides new insight into the genomic changes underlying the convergent evolution of sociality in spiders.

A study in Nature reports the identification of new germline variants associated with particular subtypes of clonal haematopoiesis of indeterminate potential (CHIP) and their links to different health outcomes.