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  • A recent study in Cell describes a developmentally important liquid-to-solid phase transition involving oskar ribonucleoprotein granules in Drosophila melanogaster oocytes.

    • Dorothy Clyde
    In Brief
  • In this Journal Club, Yukinori Okada recalls a 1987 publication that introduced a simple conceptual framework, the shared epitope hypothesis, to explain the genetic risk of rheumatoid arthritis conferred by HLA-DRB1 alleles.

    • Yukinori Okada
    Journal Club
  • In this Journal Club article, Geoff Faulkner discusses how a ground-breaking study of LINE-1 mobility in human genomes demonstrated not just a role in disease but also molecular details of the mechanisms of retrotransposition.

    • Geoffrey J. Faulkner
    Journal Club
  • In this Viewpoint, we asked six experts to give their opinions on the utility of polygenic scores, their strengths and limitations, and the remaining barriers that need to be overcome for their equitable use.

    • Iftikhar J. Kullo
    • Cathryn M. Lewis
    • Nilanjan Chatterjee
    Viewpoint
  • In this Journal Club article, Yana Bromberg discusses an early application of machine learning for protein structure prediction — a paper that shaped her career. It illustrates the value of ensuring that machine learning approaches are rooted in known biological principles.

    • Yana Bromberg
    Journal Club
  • Histone post-translational modifications (PTMs) have been mainly regarded as instructing DNA-templated processes. In this Review, Gonzalo Millán-Zambrano and colleagues describe how histone PTMs both affect and are affected by these DNA processes and should be viewed as components of a complex genome-regulating network.

    • Gonzalo Millán-Zambrano
    • Adam Burton
    • Robert Schneider
    Review Article
  • This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modelling, drug development and personalized medicine, as well as the challenges that must be overcome for organ chips to reach their full potential.

    • Donald E. Ingber
    Review Article
  • A paper in Science describes a system in synthetic yeast chromosomes in which the properties of genetic sequences change depending on the neighbouring transcriptional activity.

    • Lucia Brunello
    Research Highlight
  • DNA methylation-based predictors of health aim to predict outcomes such as exposure, phenotype or disease on the basis of genome-wide levels of DNA methylation. The authors review applications of existing DNA methylation-based predictors and highlight key statistical best practices to ensure their reliable performance.

    • Paul D. Yousefi
    • Matthew Suderman
    • Caroline L. Relton
    Review Article
  • A recent study in Nature Genetics investigates the role of DNA replication in cellular plasticity during mouse embryonic development.

    • Linda Koch
    In Brief
  • Omary et al. map shoot-borne root development at single-cell resolution in tomato to identify the origin of shoot-borne roots.

    • Linda Koch
    In Brief
  • A recent paper in Nature describes how CRISPR-based engineering of wheat confers robust resistance to powdery mildew disease without negatively impacting crop growth and yields.

    • Xian Deng
    • Xiaofeng Cao
    Research Highlight
  • In this Review, Boulias and Greer provide an overview of current approaches for detecting and mapping N6-methyl-2′-deoxyadenosine (6mA or m6dA), and discuss the evidence for its presence and functional importance in the genomes of multicellular eukaryotes.

    • Konstantinos Boulias
    • Eric Lieberman Greer
    Review Article
  • In this Perspective, Pecori et al. provide an overview of the AID/APOBEC cytidine deaminase family, discussing key structural features, how they contribute to viral and tumour evolution and how they can be harnessed for (potentially therapeutic) base-editing purposes.

    • Riccardo Pecori
    • Salvatore Di Giorgio
    • F. Nina Papavasiliou
    Perspective