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  • In this Review, the authors describe the evolutionary conservation and divergence of the meiotic recombination machinery, focusing on proteins that are required for meiotic double-strand break formation, double-strand break repair via homologous recombination and the formation of crossover and non-crossover recombinant DNA molecules.

    • Meret Arter
    • Scott Keeney
    Review Article
  • In this Perspective, Carolyn Hogg discusses the utility of genomic data to conservation and the importance of adopting a translational mindset to ensure that genomics is used to its full potential to protect Earths’ declining biodiversity.

    • Carolyn J. Hogg
  • Geopolitical instability has prompted renewed discussions on the risks of DNA technology being weaponized in international conflict. With today’s changing security environment, the authors argue that risk assessments must be broadened from genetically targeted weapons to a series of new domains.

    • Subhayan Chattopadhyay
    • Tony Ingesson
    • David Gisselsson
  • In this Review, the authors describe our current knowledge of the role of microRNAs, long non-coding RNAs and circular RNAs in disease, with a focus on cardiovascular, neurological, infectious diseases and cancer. Further, they discuss the potential use of non-coding RNAs as disease biomarkers and as therapeutic targets.

    • Kinga Nemeth
    • Recep Bayraktar
    • George A. Calin
    Review Article
  • Johnson et al. identify a WNT regulator that underlies the development and evolution of distinct colour patterning in the African striped mouse.

    • Henry Ertl
    Research Highlight
  • Chromothripsis, a complex genomic rearrangement of one (or a few) chromosomes, is frequently found in cancer genomes. The authors review methods to identify chromothripsis in cancer genomes and discuss its mechanisms of formation in micronuclei or chromosomal bridges as well as its consequences in cancer. They also highlight the link between chromothripsis and extrachromosomal DNA.

    • Ksenia Krupina
    • Alexander Goginashvili
    • Don W. Cleveland
    Review Article
  • Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for understanding human disease and the identification of drug targets.

    • Michael Attwaters
    Research Highlight
  • Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially universal process of de novo gene birth and propelled forward this field of research.

    • Li Zhao
    Journal Club
  • Legnini et al. report in Nature Methods their new optogenetic method for controlling gene expression in organoids that can be coupled with single-cell and spatial transcriptomics.

    • Henry Ertl
    Research Highlight
  • Species and communities can respond to global climate change by genetically adapting to new environmental conditions, by shifting their range or through phenotypic plasticity. This Review summarizes approaches that apply and integrate omics tools to experimentally investigate, monitor and predict these species responses.

    • Louis Bernatchez
    • Anne-Laure Ferchaud
    • Amanda Xuereb
    Review Article
  • Guhlin et al. sequenced the genomes of almost the entire extant population of the critically-endangered kākāpō, revealing genetic variants for fitness-related traits that can inform conservation strategies.

    • Michael Attwaters
    Research Highlight