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  • This Review surveys the known mechanisms of communication between RBPs and their effectors and their roles in reducing the complexity of RNA networks. The authors review the emerging roles of RBP–effector interactions in the control of RNA processing and regulation of biological outcomes, and their contribution to human health and disease.

    • Shiyang He
    • Eugene Valkov
    • Jernej Murn
    Review Article
  • A new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with potential roles in protecting from infection by other retroviruses.

    • Darren J. Burgess
    Research Highlight
  • A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.

    • Dorothy Clyde
    Research Highlight
  • A new study in Science reports the refactoring of genetic codes in Escherichia coli to create a bidirectional ‘genetic firewall’ that prevents genetic transfer from or to synthetic organisms.

    • Kirsty Minton
    Research Highlight
  • A new study reports Epigenomic MERFISH, an imaging method that combines CUT&Tag and MERFISH to interrogate histone marks representing cis-regulatory elements in single cells while preserving spatial information.

    • Linda Koch
    Research Highlight
  • In this Review, Spitale and Incarnato discuss how the application of sequencing-based RNA structure mapping methods to entire transcriptomes in living cells is providing insight into the RNA structurome, the dynamics of RNA ensembles and how RNA structure regulates cellular processes.

    • Robert C. Spitale
    • Danny Incarnato
    Review Article
  • In this Review, Chen and Liu discuss the latest developments in prime editing systems, including improvements to their editing efficiency and capabilities, as well as diverse emerging applications in research and preclinical therapeutic studies.

    • Peter J. Chen
    • David R. Liu
    Review Article
  • A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the regulatory conflict that arises when a new gene incorporates into an ancestral TAD.

    • Darren J. Burgess
    Research Highlight
  • Non-B DNA secondary structures, such as G quadruplexes, H-DNA or Z-DNA, have key roles in genetic instability and disease aetiology. The authors review the impact of non-B DNA on transcription, replication, recombination and DNA damage and repair, the mechanisms of non-B DNA-induced mutagenesis and the role of non-B DNA sequences in human disease.

    • Guliang Wang
    • Karen M. Vasquez
    Review Article
  • Guojie Zhang discusses a seminal paper by Alfred H. Sturtevant, in which he concluded based on his observations in fruitflies that the mutation rate is an evolving parameter.

    • Guojie Zhang
    Journal Club
  • Boulias and Greer review the functions of N6-methyladenosine (m6A) in RNA at the molecular, genomic and organismal level. They describe the impact of m6A deposition on RNA substrates, chromatin architecture, epigenetic regulation of gene expression and genome stability, as well as key roles of m6A in stem-cell differentiation, neurogenesis and immunity.

    • Konstantinos Boulias
    • Eric Lieberman Greer
    Review Article
  • A paper in Nature Communications describes a framework for identifying seed traits in food crops that have health-promoting effects on the gut microbiome, with implications for crop improvement approaches.

    • Dorothy Clyde
    In Brief
  • A report in Molecular Cell identifies six new triggers of target-directed miRNA degradation, which are essential for normal Drosophila melanogaster embryogenesis.

    • Dorothy Clyde
    In Brief
  • A paper in Cancer Cell reports genetic ancestry-associated differences in clinical outcomes when using tumour mutational burden as a biomarker in the context of immune checkpoint inhibitor therapy.

    • Linda Koch
    Research Highlight
  • In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that was found exclusively in Indigenous populations from the Americas. She describes how this work served as inspiration for the inclusion of more diverse populations in the 1000 Genomes Project.

    • María C. Ávila-Arcos
    Journal Club
  • Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors discuss ways in which various microbiome features at varying levels of resolution (community, strain, pathway or gene) influence human health using established examples of microbiome-associated changes linked with host outcomes.

    • Hannah VanEvery
    • Eric A. Franzosa
    • Curtis Huttenhower
    Review Article