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  • This Review discusses how transposable elements contribute to mammalian genome evolution and gene regulation through their ability to both maintain and reshape 3D genome structure.

    • Heather A. Lawson
    • Yonghao Liang
    • Ting Wang
    Review Article
  • In this Journal Club, Celine Vallot discusses two 2015 papers that introduced the concept of high-throughput RNA barcoding, which paved the way for today’s plethora of single-cell omic approaches.

    • Céline Vallot
    Journal Club
  • Tanja Woyke highlights a 2014 study by Kashtan et al., who applied single-cell genomics to populations of the marine cyanobacterium Prochlorococcus, revealing hundreds of subpopulations with distinct genomic backbones of this wild uncultured microorganism.

    • Tanja Woyke
    Journal Club
  • In this Perspective, Lim et al. discuss the potential benefits of, and the challenges associated with, translating single-cell genomic approaches from research to clinical settings.

    • Jennifer Lim
    • Venessa Chin
    • Joseph E. Powell
  • A study in Molecular Cell reveals how CTCF and cohesin contribute to genome organization through their roles in forming and stacking chromatin loops.

    • Dorothy Clyde
    Research Highlight
  • The authors review genetic studies of sensorineural hearing impairment (SNHI) and their resulting insights into the molecular mechanisms underlying auditory system function. They also discuss preclinical studies of inner-ear gene therapy and key translational opportunities and challenges for treating monogenic forms of SNHI and associated balance disorders.

    • Christine Petit
    • Crystel Bonnet
    • Saaïd Safieddine
    Review Article
  • Recent systems biology and single-cell approaches have revealed the impact of the microenvironment, lineage specification and cell identity, and the genome on epithelial–mesenchymal plasticity (EMP). In addition, cell memory (hysteresis) and cellular noise can drive stochastic transitions between cell states. The authors review these forces and the regulatory mechanisms that stabilize EMP states or facilitate epithelial–mesenchymal transitions (EMTs).

    • Jef Haerinck
    • Steven Goossens
    • Geert Berx
    Review Article
  • Wagner et al. report an organism-wide map of non-coding RNA expression in ageing and rejuvenated mice, identifying a set of broadly deregulated microRNAs that may act as systemic regulators of ageing.

    • Linda Koch
    Research Highlight
  • Differences in facial morphology distinguish vertebrates. Here, Selleri and Rijli discuss advances in multi-omics and single-cell technologies linking genes, transcriptional networks and epigenetic landscapes to the establishment of facial patterning and its variation, with an emphasis on normal and abnormal craniofacial morphogenesis.

    • Licia Selleri
    • Filippo M. Rijli
    Review Article
  • In this Review, the authors describe the emerging field of single-cell genetics, which lies at the intersection of single-cell genomics and human genetics. They review the first single-cell expression quantitative trait loci studies, which combine single-cell information with genotype data at the population scale and thereby link genetic variation to the cellular processes underpinning key aspects of human biology and disease.

    • Anna S. E. Cuomo
    • Aparna Nathan
    • Joseph E. Powell
    Review Article
  • Mutations that affect primary cilia cause ciliopathies with variable severity and expressivity. The diversity of cilia across cell types, tissues and developmental stages enables their function as versatile signalling hubs but may underlie the disconnect between genotype and phenotype. This Review examines the structural and functional diversity of primary cilia, their dynamic regulation in different cellular and developmental contexts and their disruption in disease.

    • Pleasantine Mill
    • Søren T. Christensen
    • Lotte B. Pedersen
    Review Article
  • In this Journal Club, Loic Yengo discusses a study by Tenesa et al., who used height as a model complex trait to estimate the degree to which height similarity between spouses is caused by mate choice.

    • Loic Yengo
    Journal Club
  • Sophie von der Heyden highlights a paper by Barber et al. that examined variations in the genetic structuring of populations of the mantis shrimp Haptosquilla pulchella, furthering our understanding of the evolutionary dynamics of marine species.

    • Sophie von der Heyden
    Journal Club