Browse Articles

Filter By:

  • Practitioners in the field of single-cell omics are now faced with diverse options for analytical tools to process and integrate data from various molecular modalities. In an Expert Recommendation article, the authors provide guidance on robust single-cell data analysis, including choices of best-performing tools from benchmarking studies.

    • Lukas Heumos
    • Anna C. Schaar
    • Fabian J. Theis
    Expert Recommendation
  • Zhang et al. describe two technologies for the spatially resolved co-mapping of epigenome and transcriptome at near single-cell resolution.

    • Kirsty Minton
    Research Highlight
  • In this Review, the authors discuss the latest advances in profiling multiple molecular modalities from single cells, including genomic, transcriptomic, epigenomic and proteomic information. They describe the diverse strategies for separately analysing different modalities, how the data can be computationally integrated, and approaches for obtaining spatially resolved data.

    • Katy Vandereyken
    • Alejandro Sifrim
    • Thierry Voet
    Review Article
  • A paper in Science reports that circadian gene expression in humans is affected by sex and age, findings that might explain differential disease prevalence among these groups and have implications for treatment.

    • Dorothy Clyde
    Research Highlight
  • Julio Collado-Vides recalls two 2005 publications that provide a conceptual framework based on a statistical thermodynamics approach to quantitatively model the regulatory activity at promoters subject to regulation by multiple transcription factors.

    • Julio Collado-Vides
    Journal Club
  • This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture methods to detect the formation of self-interacting chromatin regions, known as topologically associating domains (TADs).

    • Elisa Oricchio
    Journal Club
  • Magda Bienko highlights a landmark paper by Lieberman-Aiden et al., which in 2009 reported the development of high-throughput chromosome conformation capture (Hi-C), revolutionizing the field of 3D genome biology.

    • Magda Bienko
    Journal Club
  • Two studies have revealed that the characteristic distribution of N6-methyladenosine (m6A) — an RNA modification known to be functionally important for mRNA metabolism among other processes — in mRNA is shaped by the exon junction complex during splicing.

    • Dorothy Clyde
    Research Highlight
  • Environmental pollutants have been shown to disrupt molecular mechanisms underlying common complex diseases. The authors review the interplay of environmental stressors with the human genome and epigenome as well as other molecular processes, such as production of extracellular vesicles, epitranscriptomic changes and mitochondrial changes, through which the environment can exert its effects.

    • Haotian Wu
    • Christina M. Eckhardt
    • Andrea A. Baccarelli
    Review Article
  • In this Review, Munir Pirmohamed provides an overview of the current state of the pharmacogenomics field, using examples of clinically relevant drug–gene associations, before outlining the steps needed for implementation of pharmacogenomics into clinical practice. The role of pharmacogenomics in drug discovery and development is also considered.

    • Munir Pirmohamed
    Review Article
  • Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals into self-assembling protein filaments.

    • Darren J. Burgess
    Research Highlight
  • In this Journal club, Meritxell Huch recalls a dogma postulated by Hayflick in 1961, that the capacity for propagating primary epithelial cells with normal ploidy is limited — a theory that persisted until the advent of organoid cultures.

    • Meritxell Huch
    Journal Club