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  • Inducible protein degradation technologies enable the depletion of loop extrusion factors within short time frames, leading to the rapid reconfiguration of the 3D genome. Nora and de Wit review insights from degron approaches into the molecular factors controlling genome folding and how these findings have changed our understanding of genome organization, including its role in transcription.

    • Elzo de Wit
    • Elphège P. Nora
    Review Article
  • A paper in Molecular Cell reports the characterization of a second functional light strand promoter (LSP2) in the mitochondrial genome, challenging the view that mitochondrial DNA replication and gene expression are coupled by their reliance on a single light strand promoter (LSP).

    • Dorothy Clyde
    Research Highlight
  • Four papers in Science use single-cell, single-nucleus and spatial transcriptomic profiling of reptilian and amphibian brain tissue to provide insights into the evolution of vertebrate forebrains.

    • Kirsty Minton
    Research Highlight
  • Mendelian defects in genes encoding factors that regulate telomere length, structure and function cause telomeropathies, or telomere biology disorders (TBDs). The authors review confirmed as well as potential TBD-causing genes and their main functions in telomere biology. They also discuss genetic features that underlie the complex nature of these diseases.

    • Patrick Revy
    • Caroline Kannengiesser
    • Alison A. Bertuch
    Review Article
  • This Review discusses how chromosome tracing has deepened our understanding of the role of 3D chromatin topology in transcriptional regulation by helping to resolve open questions and opposing models rising from data generated by sequencing-based approaches, such as 3C and HiC.

    • Antonina Hafner
    • Alistair Boettiger
    Review Article
  • By studying the closest extant unicellular relatives of animals and fungi, a study in Nature contrasts the evolutionary trajectories leading to the origin of these groups.

    • Linda Koch
    Research Highlight
  • Cooper et al. report in Science the use of massively parallel reporter assays and CRISPR-based validation to characterize the function of noncoding variants in dementia.

    • Kirsty Minton
    Research Highlight
  • A new study in Cell has characterized genome-wide dosage sensitivity for 54 human disorders, providing insight into the causal genes and disease mechanisms associated with rare copy-number variants.

    • Dorothy Clyde
    Research Highlight
  • The circadian system and sleep physiology are linked to myriad biological processes, the disruption of which is detrimental to human health. Here, the authors review insights from genetic studies of human circadian and sleep phenotypes and disorders, with a focus on those with causal contributions to other complex diseases.

    • Jacqueline M. Lane
    • Jingyi Qian
    • Richa Saxena
    Review Article
  • Sex-specific morphs exhibit phenotypes that differ between the sexes and typically include many different traits. Here, the author reviews recent genomic and transcriptomic studies that are yielding new insights into the evolutionary origin and development of sex-specific morphs in a wide range of animal species.

    • Judith E. Mank
    Review Article
  • In this Review, the authors discuss our latest understanding of extrachromosomal DNA (ecDNA), a type of circular DNA element commonly found in cancers. They discuss ecDNA properties, including oncogene amplifications and transcriptional hub formation, as well as opportunities for therapeutic interventions.

    • Eunhee Yi
    • Rocío Chamorro González
    • Roel G. W. Verhaak
    Review Article
  • A study in Nature describes ‘DNA Typewriter’, a prime-editing-based DNA recording technology that can capture the order of large numbers of distinct molecular events in mammalian cells.

    • Kirsty Minton
    Research Highlight
  • Spatial omics methods enable the charting of cellular heterogeneity, complex tissue architectures and dynamic changes during development and disease. The authors review the developing landscape of in situ spatial transcriptome, genome and proteome technologies and highlight their impact on basic and translational research.

    • Jeffrey R. Moffitt
    • Emma Lundberg
    • Holger Heyn
    Review Article
  • In this Review, Preissl, Gaulton and Ren discuss single-cell epigenomic methods and data analysis tools, their readiness for profiling cis-regulatory elements in human tissues and the insight they can provide into dynamic, context-specific gene regulation.

    • Sebastian Preissl
    • Kyle J. Gaulton
    • Bing Ren
    Review Article
  • In this Perspective, the authors discuss how regulated alternative splicing can generate phenotypic diversity and outline emerging evidence that alternative splicing contributes to adaptation and species divergence.

    • Charlotte J. Wright
    • Christopher W. J. Smith
    • Chris D. Jiggins
    Perspective
  • Two recent studies report microbial genome and gene catalogues that archive oceanic and glacial genomic and functional diversity at scale and yield insights into their biosynthetic potential.

    • Linda Koch
    Research Highlight