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  • Two new papers in Nature report copy-number-based classification systems across cancer types that provide routes for personalized therapy.

    • Darren J. Burgess
    Research Highlight
  • A report in Cell takes single-cell CRISPR screens to genome scale and demonstrates how the transcriptional phenotypes can be used to resolve gene functions.

    • Lucia Brunello
    Research Highlight
  • Molecular measures of biological ageing based on high-throughput omics technologies are enabling the quantitative characterization of ageing. The authors review how epigenomic, transcriptomic, proteomic, metabolomic and other omics data can be harnessed using machine learning to build ‘ageing clocks’.

    • Jarod Rutledge
    • Hamilton Oh
    • Tony Wyss-Coray
    Review Article
  • In this Comment, the authors highlight caveats about using African ethnicities as population categories in genomics research and emphasize the need for an Africa-oriented humanities research agenda to inform genomics research.

    • Henri-Michel Yéré
    • Mavis Machirori
    • Jantina De Vries
  • In this Review, Kim and Kingston discuss the compositional and mechanistic diversity of Polycomb repressive complexes (PRCs) and how their context-dependent formation may be required for proper epigenetic regulation in development.

    • Jongmin J. Kim
    • Robert E. Kingston
    Review Article
  • tRNA function and gene expression profiles are dynamically regulated by post-transcriptional tRNA modifications. Here, Orellana et al. discuss the canonical role of tRNAs in mRNA translation, focusing on alterations in tRNA abundance or function implicated in human diseases.

    • Esteban A. Orellana
    • Elisabeth Siegal
    • Richard I. Gregory
    Review Article
  • In this Editorial, we reflect on the field’s responsibility around the potential uses and abuses of genetics and genomics research.

  • Gegenhuber et al. now show that, in mice, a neonatal surge in oestradiol activates oestrogen receptor-α to drive a sustained male-typical gene expression programme that determines brain sexual differentiation.

    • Katharine H. Wrighton
    Research Highlight
  • Dupont and Wickström review the current understanding of how mechanical forces regulate chromatin state and gene expression and discuss the importance of this mechanosensitive gene regulation to physiology and disease.

    • Sirio Dupont
    • Sara A. Wickström
    Review Article
  • Commemorating the 200th birthday of Gregor Mendel, Kim Nasmyth reflects on Mendel’s life and legacy and how his work has shaped and defined the field of modern genetics.

    • Kim Nasmyth
  • A new study presents GLUE (graph-linked unified embedding), a generalizable computational framework for integrating unpaired single-cell multi-omics data and for inferring regulatory interactions.

    • Linda Koch
    In Brief
  • A recent study reports the development of Stereo-seq (spatial enhanced resolution omics-sequencing) and its application to generate a spatiotemporal transcriptomic atlas of mouse organogenesis.

    • Linda Koch
    In Brief
  • Gene loss is followed by the rapid emergence of new phenotypes owing to compensatory evolution, finds a recent study using experimental evolution of budding yeast lineages.

    • Linda Koch
    In Brief
  • Levo et al. used quantitative single-cell live imaging to analyse the transcriptional dynamics of fly paralogues separated by long genomic distances, to determine whether they are co-regulated.

    • Linda Koch
    In Brief
  • Publicly available sequencing data can be used as external common controls for rare variant analyses but cautious sample ascertainment and processing is needed to avoid bias and confounding. The authors review opportunities and challenges for the robust use of common controls in genetic studies, including study design, infrastructure and quality control considerations.

    • Genevieve L. Wojcik
    • Jessica Murphy
    • Audrey E. Hendricks
    Review Article
  • Lillian Musila highlights a paper by Quick et al., which reported the use of portable nanopore sequencing for on-site, real-time genomic surveillance during the 2014–2016 Ebola virus epidemic.

    • Lillian Musila
    Journal Club