A shelf of pharmaceutical pills in the shape of a helix


Munir Pirmohamed reviews the pharmacogenomics field using examples of clinically relevant drug–gene associations, as well as the steps needed for implementing pharmacogenomics into clinical practice.

  • Munir Pirmohamed
Review Article


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    This Nature Milestone provides a perspective of major genomic sequencing-related developments in the 21st century — from the first human reference genome, through methodological breakthroughs, to the impact of sequencing on fields as diverse as microbiology, cancer and palaeogenetics.

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    This Nature Milestone celebrates two decades of breakthroughs in basic, translational and clinical research, which have revolutionized our understanding and management of cancer.

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    The editors of Nature Reviews Genetics will be posting about the latest developments in research and policy, and providing news about the journal. If you have any questions or feedback for us, get in touch by email or on Twitter.

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  • Mustafa Mir reflects on a 1976 paper by McKnight and Miller, in which they developed a technique to directly visualize gene regulatory dynamics.

    • Mustafa Mir
    Journal Club
  • Logsdon et al. report the second complete sequence of all centromeres from a single human genome, enabling comparative analyses of the variation in tandemly repeating α-satellite DNA.

    • Kirsty Minton
    Research Highlight
  • In this Comment, Lamkin and Gymrek discuss recent results that suggest that the systematic incorporation of tandem repeats into complex trait analyses will yield a rich source of causal variants and new biological insights.

    • Michael Lamkin
    • Melissa Gymrek
  • In this Tools of the Trade article, Samuel Gould explains how prime editing sensors can improve experimental efficiency and can be designed using a computational tool he created and named PEGG.

    • Samuel I. Gould
    Tools of the Trade

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