Human organs-on-chips for disease modelling, drug development and personalized medicine
This Review summarizes how human organ chip systems have been used to model complex diseases and rare genetic disorders
This Review summarizes how human organ chip systems have been used to model complex diseases and rare genetic disorders
In this Review, the authors summarize our current understanding of nuclear pre-mRNA and mRNA decay pathways. They describe how aberrantly processed mRNAs are targeted for decay in the nucleus and how this process is regulated to finely control gene expression.