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Measuring biological age using omics data

  • Jarod Rutledge
  • Hamilton Oh
  • Tony Wyss-Coray
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    Gregor Johann Mendel, considered by many the ‘father of modern genetics’, was born 200 years ago, on 20 July 1822. In commemoration of this milestone, this Nature Collection brings together articles that explore the origins of genetics and reflect on Mendel’s legacy, which continues to shape the field to this day.

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  • A new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with potential roles in protecting from infection by other retroviruses.

    • Darren J. Burgess
    Research Highlight
  • A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.

    • Dorothy Clyde
    Research Highlight
  • A new study in Science reports the refactoring of genetic codes in Escherichia coli to create a bidirectional ‘genetic firewall’ that prevents genetic transfer from or to synthetic organisms.

    • Kirsty Minton
    Research Highlight
  • A new study reports Epigenomic MERFISH, an imaging method that combines CUT&Tag and MERFISH to interrogate histone marks representing cis-regulatory elements in single cells while preserving spatial information.

    • Linda Koch
    Research Highlight
  • A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the regulatory conflict that arises when a new gene incorporates into an ancestral TAD.

    • Darren J. Burgess
    Research Highlight
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Nobel Prize in Physiology or Medicine 2022

The 2022 Nobel Prize in Physiology or Medicine was awarded to Svante Pääbo "for his discoveries concerning the genomes of extinct hominins and human evolution".
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