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Monitoring species with genomics

Understanding and monitoring how organisms respond to human-driven climate change is a major priority for the conservation of biodiversity in a rapidly changing environment.

  • Louis Bernatchez
  • Anne-Laure Ferchaud
  • Amanda Xuereb
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    This Milestone timeline provides a perspective of major genomic sequencing-related developments in the 21st century — from the first human reference genome, through methodological breakthroughs, to the impact of sequencing on fields as diverse as microbiology, cancer and palaeogenetics.

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    Recent technological advances are providing unprecedented opportunities to analyse the complexities of biological systems at the single-cell level. Various crucial biological phenomena are either invisible or only partially characterized when interrogated using standard analyses that average data across a bulk population of cells.

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  • A study in Nature describes how single-cell expression data can be used to understand gene regulatory landscapes in bacteria.

    • Michael Attwaters
    Research Highlight
  • Amnon Koren recalls two papers from 2001 and 2002 that laid the foundations for a new field by using microarrays to measure DNA replication timing across the genome.

    • Amnon Koren
    Journal Club
  • Vincent Courdavault and Nicolas Papon highlight two articles in Nature, published in 2006 and 2013, that reported the biosynthesis of a complex natural plant product to treat malaria in engineered yeast.

    • Vincent Courdavault
    • Nicolas Papon
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Image of part of a cancer genome circus plot

Cancer genomics

This collection showcases how cancer genomics has informed our understanding of cancer pathogenesis, unravelled potential future therapeutic targets and driven advances that are starting to translate into the clinic. This resource provides a comprehensive bench-to-bedside overview of cancer genomics, which will be useful to researchers and clinicians alike.
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