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Genomics for monitoring and understanding species responses to global climate change

  • Louis Bernatchez
  • Anne-Laure Ferchaud
  • Amanda Xuereb
Review Article

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Volume 25 Issue 10
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    This Nature Milestone provides a perspective of major genomic sequencing-related developments in the 21st century — from the first human reference genome, through methodological breakthroughs, to the impact of sequencing on fields as diverse as microbiology, cancer and palaeogenetics.

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    This Nature Milestone celebrates two decades of breakthroughs in basic, translational and clinical research, which have revolutionized our understanding and management of cancer.

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Latest Reviews & Analysis

    • Metabologenomics integrates multi-omics data into genome-scale metabolic models (GEMs) to analyse complex metabolic networks. Mardinoglu and Palsson review advancements in GEMs at the global, cell- and tissue-specific, microbiome and whole-body levels, with insights into their applications towards improving health care.

      • Adil Mardinoglu
      • Bernhard Ø. Palsson
      Review Article

    • Toxicogenomics leverages molecular data to predict toxicological effects. In this Review, the authors summarize innovations in transcriptomics and emerging methods, such as single-cell technologies and multi-omics, that offer detailed insights into toxicological mechanisms to enhance hazard prediction and risk assessment.

      • Matthew J. Meier
      • Joshua Harrill
      • Carole L. Yauk
      Review Article

    • Mosaic variegated aneuploidy is a rare condition in which the copy number of different chromosomes varies across some cells within an individual. In this Review, the authors discuss the genetic underpinnings and clinical manifestations of this condition and relate these findings to the consequences of chromosomal instability more broadly.

      • Marcos Malumbres
      • Carolina Villarroya-Beltri
      Review Article

    • In this Review, the authors provide an overview of the roles of individual histone variants in multiple processes, including gene regulation, DNA replication and DNA repair, and the cellular consequences of their dysfunction.

      • Lee H. Wong
      • David J. Tremethick
      Review Article

    • In this Review, Smith et al. describe DNA methylation landscapes that emerge over mammalian development and within key disease states, as well as how different methyltransferases interface with histone modifications and other proteins to create and maintain them.

      • Zachary D. Smith
      • Sara Hetzel
      • Alexander Meissner
      Review Article

News & Comment

  • In this Journal Club, Alejo Rodriguez-Fratelli discusses a paper by Spudich and Koshland Jr that characterized non-genetic cell individuality in bacteria, a concept with emerging relevance to cancer progression.

    • Alejo E. Rodriguez-Fraticelli
    Journal Club

  • A study in Science investigating bacterial defence mechanisms against phages reports a novel mode of gene regulation through reverse transcription of a non-coding RNA template, leading to the formation of a toxic repetitive gene.

    • Linda Koch
    Research Highlight

  • Yimiao Qu and Kyle Loh discuss a 2004 paper by Xie et al., who demonstrated that B cells can be reprogrammed into macrophages through the enforced expression of a single transcription factor, providing insights into cellular plasticity and lineage conversion.

    • Yimiao Qu
    • Kyle M. Loh
    Journal Club

  • In this Comment, Veltman and Tüttelmann call on geneticists to further study male infertility and help to develop diagnostic strategies using state-of-the-art genomic approaches.

    • Joris A. Veltman
    • Frank Tüttelmann
    Comment

  • Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis elegans by manipulating the trimethylation of histone H3 lysine 4 (H3K4me3) in the parental generation.

    • Merly C. Vogt
    Journal Club

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Single-cell omics

Many biological phenomena are either invisible or only partially characterized when interrogated using standard analyses that average data across a bulk population of cells. Now, technological advances are providing unprecedented opportunities to analyse the complexities of biological systems at the single-cell level. High-throughput analyses of the genomes, transcriptomes and proteomes of single cells are yielding novel and important insights into diverse processes such as development, gene-expression dynamics, tissue heterogeneity and disease pathogenesis. In this Focus issue, we highlight the transformative potential of single-cell omics approaches.
  • Linda Koch
Focus

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