In this Review, Chen and Liu discuss the latest developments in prime editing systems, including improvements to their editing efficiency and capabilities, as well as diverse emerging applications in research and preclinical therapeutic studies.

This Review discusses how chromosome tracing has deepened our understanding of the role of 3D chromatin topology in transcriptional regulation by helping to resolve open questions and opposing models rising from data generated by sequencing-based approaches, such as 3C and HiC.

In this Perspective, the authors discuss how regulated alternative splicing can generate phenotypic diversity and outline emerging evidence that alternative splicing contributes to adaptation and species divergence.

A study in Nature identified the presumed owner or maker of a 20,000-year-old pendant.

A study in Molecular Cell reveals how CTCF and cohesin contribute to genome organization through their roles in forming and stacking chromatin loops.

A study in Science describes a rationally designed synthetic gene oscillator that prolongs the lifespan of yeast.

Wagner et al. report an organism-wide map of non-coding RNA expression in ageing and rejuvenated mice, identifying a set of broadly deregulated microRNAs that may act as systemic regulators of ageing.

A new study in Nature Genetics describes how changes in the levels of transcription factors can affect normal-range phenotypic variation and disease.

Sen et al. describe the epigenetic changes that underpin aberrant transcription initiation during senescence and ageing.