Nandita Garud recalls two seminal papers by Hermisson and Pennings that provide a framework for understanding when adaptation should be gradual versus rapid.

Julio Collado-Vides recalls two 2005 publications that provide a conceptual framework based on a statistical thermodynamics approach to quantitatively model the regulatory activity at promoters subject to regulation by multiple transcription factors.

This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture methods to detect the formation of self-interacting chromatin regions, known as topologically associating domains (TADs).

Zhang et al. describe two technologies for the spatially resolved co-mapping of epigenome and transcriptome at near single-cell resolution.

A new study in Science identifies a role for USB1 in deadenylating microRNAs to regulate blood development.

Two studies analysing ancient hunter-gatherer genomes report detailed insights into the history and interactions of West Eurasian hunter-gatherer groups and highlight the genetic replacement of entire Ice Age populations.

A new study in Cell uses epigenome engineering to confer transgenerational inheritance of DNA methylation states and metabolic traits in mice.

A study in Nature Biotechnology reports a whole-genome sequencing methodology that combines genome and epigenome sequencing in a single run.

A paper in Science reports that circadian gene expression in humans is affected by sex and age, findings that might explain differential disease prevalence among these groups and have implications for treatment.