P. Morgan, Springer Nature

RNA: a double-edged sword in genome maintenance

Latest Reviews

  • Review Article |

    The effects of genetic variation on the adaptive potential of species depend on the frequencies of alleles at other loci in the individual or in the population, and the patterns of spatio-temporal co-occurrence between alleles in interacting species. This Review explores these population and community genomic contexts and their direct and indirect effects on biodiversity, ecosystems and people.

    • Madlen Stange
    • , Rowan D. H. Barrett
    •  & Andrew P. Hendry
  • Perspective |

    Recent studies have demonstrated that concomitant activity of de novo methylation and demethylation machineries results in rapid turnover of DNA methylation in certain contexts. The authors review this phenomenon and propose that DNA methylation turnover may facilitate key lineage decisions.

    • Aled Parry
    • , Steffen Rulands
    •  & Wolf Reik
  • Review Article |

    Deep resequencing has revealed extreme genetic variation in mitochondrial genomes at multiple levels. This heterogeneity has implications for the origins of human mitochondrial DNA mutations as well as their impact on rare and common human diseases, including cancer.

    • James B. Stewart
    •  & Patrick F. Chinnery
  • Review Article |

    In this Review, Cenik and Shilatifard focus on two families of Trithorax group proteins: COMPASS histone H3 lysine 4 methyltransferase complexes and SWI/SNF chromatin remodelling complexes. They discuss the roles of these complexes in gene regulation, development and disease.

    • Bercin K. Cenik
    •  & Ali Shilatifard
  • Review Article |

    Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. In this Review, Dai, Ramesh and Locasale discuss the metabolic regulation of diverse types of chromatin modifications and the functional consequences of these modifications at the molecular, cellular and organismal levels, as well as influences from diet and microbiota.

    • Ziwei Dai
    • , Vijyendra Ramesh
    •  & Jason W. Locasale
  • Review Article |

    In this Review, Suhre, McCarthy and Schwenk describe how combining genetics with plasma proteomics is providing notable insights into human disease. As changes in the circulating proteome are often an intermediate molecular readout between a genetic variant and its organismal effect, proteomics can enable a deeper understanding of disease mechanisms, clinical biomarkers and therapeutic opportunities.

    • Karsten Suhre
    • , Mark I. McCarthy
    •  & Jochen M. Schwenk

News & Comment

  • Research Highlight |

    A recent study re-casts proteomic analyses as a DNA sequencing problem; by fusing in vivo-expressed proteins to their encoding mRNA, molecular interactions can be identified and quantified through high-throughput nucleic-acid sequencing.

    • Linda Koch
  • Research Highlight |

    The GTEx consortium reports results from its third and final phase in several new papers. They provide unprecedented detail of human gene expression regulation across tissues.

    • Darren J. Burgess
  • Research Highlight |

    A study in Molecular Biology and Evolution reports de novo genome sequences for 17 bumblebee species spanning all 15 subgenera. This valuable resource should provide a deeper biological understanding of these commercially and ecologically important pollinators.

    • Dorothy Clyde
  • Research Highlight |

    A study in Nature Genetics reports the analysis of 172 whole-genome sequences of indigenous African cattle and identifies loci associated with environmental adaptations among crossbred animals.

    • Linda Koch
  • Research Highlight |

    A study in Science suggests that regeneration-responsive enhancers drive a regeneration response programme (RRP) in killifish and zebrafish and that changes in RRPs might have facilitated the loss of regenerative capacity in vertebrates.

    • Katharine H. Wrighton
  • Research Highlight |

    Two papers in Cell report large-scale genome-wide association studies that provide new insights into the genetic architecture of haematopoietic phenotypes and emphasize the importance of large, diverse data sets.

    • Dorothy Clyde


20th Anniversary

Springer Nature Limited

20th Anniversary

October 2020 marks the 20th anniversary of the launch of Nature Reviews Genetics. To celebrate this milestone, we have delved into our archives to curate a Collection of cutting-edge articles, historical pieces and thought-provoking commentaries and opinions. Featuring a range of article types, including Reviews, Perspectives, Viewpoints and Comments, this Collection provides a glimpse of the genetics and genomics field over the past two decades.


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