Human organs-on-chips for disease modelling, drug development and personalized medicine
This Review summarizes how human organ chip systems have been used to model complex diseases and rare genetic disorders
This Review summarizes how human organ chip systems have been used to model complex diseases and rare genetic disorders
Targeted genome modification using CRISPR–Cas genome editing, base editing or prime editing is driving base research in plants and precise molecular breeding. The authors review the technological principles underlying these methods, approaches for their delivery in plants, and emerging crop-breeding strategies based on targeted genome modification.