• Stylized multi-coloured Circos plot

    The past two decades have witnessed extraordinary technological and computational advances in nucleic acid sequencing. This Milestone timeline provides a perspective of major genomic sequencing-related developments in the 21st century.

  • Immune cells attacking cancer cells

    The immune system is constantly on the lookout for threats but can fail to spot cancer. Now, advanced sequencing technologies are enabling scientists to investigate the unique genetics of both cancers and immune responses in individual patients. This means researchers can develop treatments that boost the immune system and help the body win its battle against cancer.

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    The editors of Nature Reviews Genetics will be posting about the latest developments in research and policy, and providing news about the journal. If you have any questions or feedback for us, get in touch by email or on Twitter.

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    Finding it hard to navigate the flood of scientific literature? The Nature Reviews journals filter and highlight the most impactful research. Take a look at this animation to learn how Nature Reviews Genetics can help you stay up-to-date, or visit


    • Spatial omics methods enable the charting of cellular heterogeneity, complex tissue architectures and dynamic changes during development and disease. The authors review the developing landscape of in situ spatial transcriptome, genome and proteome technologies and highlight their impact on basic and translational research.

      • Jeffrey R. Moffitt
      • Emma Lundberg
      • Holger Heyn
      Review Article
    • In this Review, Preissl, Gaulton and Ren discuss single-cell epigenomic methods and data analysis tools, their readiness for profiling cis-regulatory elements in human tissues and the insight they can provide into dynamic, context-specific gene regulation.

      • Sebastian Preissl
      • Kyle J. Gaulton
      • Bing Ren
      Review Article
    • In this Perspective, the authors discuss how regulated alternative splicing can generate phenotypic diversity and outline emerging evidence that alternative splicing contributes to adaptation and species divergence.

      • Charlotte J. Wright
      • Christopher W. J. Smith
      • Chris D. Jiggins
    • Molecular measures of biological ageing based on high-throughput omics technologies are enabling the quantitative characterization of ageing. The authors review how epigenomic, transcriptomic, proteomic, metabolomic and other omics data can be harnessed using machine learning to build ‘ageing clocks’.

      • Jarod Rutledge
      • Hamilton Oh
      • Tony Wyss-Coray
      Review Article
  • A study in Nature describes ‘DNA Typewriter’, a prime-editing-based DNA recording technology that can capture the order of large numbers of distinct molecular events in mammalian cells.

    • Kirsty Minton
    Research Highlight
  • Two recent studies report microbial genome and gene catalogues that archive oceanic and glacial genomic and functional diversity at scale and yield insights into their biosynthetic potential.

    • Linda Koch
    Research Highlight
  • Two new papers in Nature report copy-number-based classification systems across cancer types that provide routes for personalized therapy.

    • Darren J. Burgess
    Research Highlight
Green or yellow, smooth or wrinkly peas in and out of pods.

Celebrating Mendel

Gregor Johann Mendel, considered by many the ‘father of modern genetics’, was born 200 years ago, on 20 July 1822.


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