Patrick Morgan

High-throughput determination of RNA structures

Latest Reviews

  • Review Article |

    In this Review, Sheth and Wang describe emerging synthetic biology approaches for using DNA as a memory device for recording cellular events, including the various methodological steps from detecting diverse signals, converting them into DNA alterations and reading out and interpreting the recorded information. Furthermore, they discuss potential applications as biotechnological and environmental biosensors.

    • Ravi U. Sheth
    •  & Harris H. Wang
  • Review Article |

    The repetitive nature of transposable elements (TEs) creates bioinformatic challenges that frequently result in them being disregarded (‘masked’) in analyses. As physiological and pathological roles for TEs become increasingly appreciated, this Review discusses bioinformatics tools dedicated to TE analysis, including for genomic annotation, TE classification, identifying polymorphisms and assessing likely functional impacts.

    • Patricia Goerner-Potvin
    •  & Guillaume Bourque
  • Review Article |

    Organoids are 3D structures derived from stem cells that recapitulate some key characteristics of real organs. The authors review recent progress in organoid derivation and applications and outline how advances in other disciplines might lead to more physiologically relevant organoids.

    • Giuliana Rossi
    • , Andrea Manfrin
    •  & Matthias P. Lutolf
  • Review Article |

    The genomes of East African cichlid fish have yielded new insights into adaptive radiation and suggest that specific genomic features underlie their propensity for explosive diversification. The author reviews these findings and the challenges of reconstructing the evolutionary history of rapidly diversifying clades.

    • Walter Salzburger
  • Review Article |

    This Review discusses how stem cell bioengineering can advance regenerative medicine by giving insight into the design principles that underlie different levels of stem cell systems — from the inner circuitry in single cells and the stem cell niche to systemic interactions between organs and tissues.

    • Mukul Tewary
    • , Nika Shakiba
    •  & Peter W. Zandstra
  • Review Article |

    High-throughput sequencing technology is enabling the structures of RNA to be determined on an unprecedented scale, providing insights into the relationship between the structures adopted by RNAs and the functions they perform in the cell.

    • Eric J. Strobel
    • , Angela M Yu
    •  & Julius B. Lucks

News & Comment

  • Research Highlight |

    A study in Nature characterizes the genome of Denisova 11 and reveals her to be a first-generation offspring of Neanderthal and Denisovan parents, thereby providing direct evidence of genetic mixing between genetically distinct groups of archaic hominins.

    • Dorothy Clyde
  • Research Highlight |

    A study in Nature describes RNA velocity, which is a computational method to derive dynamic gene expression information from static single-cell RNA sequencing data. It provides valuable insights into developmental trajectories of cells.

    • Darren J. Burgess
  • Research Highlight |

    A study in Science reports the successful application of CRISPR–Cas genome editing to track and reconstruct developmental lineages in the mouse.

    • Linda Koch
  • Research Highlight |

    A Nature Genetics study reports the findings of a genome-wide associationstudy of educational attainment in 1.1 million individuals.

    • Michelle Trenkmann
  • Research Highlight |

    A study in Cell challenges the existing notion of the evolution of FOXP2 as a human-specific language gene.

    • Rebecca Furlong
  • Research Highlight |

    A new RNA sequencing technology reported in Science uses hydrogel-tissue chemistry to enable gene expression profiling in intact tissues.

    • Linda Koch

Collection

Stem cells from development to the clinic

Miguel Quiros and Asma Nusrat

Stem cells from development to the clinic

Stem cells are well on their way into the clinic and can be used in a variety of applications, such as disease modelling, drug screening and for regenerative medicine. This collection showcases research articles, reviews and protocols from across the Nature journals to highlight the striking advances made in basic and translational stem cell research.

Christine Weber, Ann Le Good

Nature events Directory