Patrick Morgan

Demographic history, selection and functional diversity of the canine genome

Latest Reviews

  • Science and Society |

    Including diverse populations in genomic studies has the potential to improve the use of genomic data in the clinic. Here, members of the National Human Genome Research Institute review the benefits of increasing diversity, the challenges to overcome and key recommendations for how to achieve this goal.

    • Lucia A. Hindorff
    • , Vence L. Bonham
    • , Lawrence C. Brody
    • , Margaret E. C. Ginoza
    • , Carolyn M. Hutter
    • , Teri A. Manolio
    •  & Eric D. Green
  • Review |

    The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data.

    • Andrew E. Teschendorff
    •  & Caroline L. Relton
  • Review |

    Next-generation sequencing has the potential to support public health surveillance systems to improve the early detection of emerging infectious diseases. This Review delineates the role of genomics in rapid outbreak response and the challenges that need to be tackled for genomics-informed pathogen surveillance to become a global reality.

    • Jennifer L. Gardy
    •  & Nicholas J. Loman
  • Review |

    Disease-resistant crops have the potential to reduce crop losses. This Review discusses how advances in genetic and genomic technologies are contributing to efforts by plant breeders to generate durable, broad-spectrum disease resistance in crop plants.

    • Rebecca Nelson
    • , Tyr Wiesner-Hanks
    • , Randall Wisser
    •  & Peter Balint-Kurti
  • Analysis |

    Characterizing the essentiality of human genes provides insights into gene function and genome evolution and facilitates the clinical interpretation of genetic variants. This article analyses essentiality metrics based on the statistical intolerance to loss-of-function mutations in human population sequencing studies and discusses commonalities and distinctions relative to data sets from knockout mice and functional genomics screens in human cell culture. Implications for disease genetics and extrapolation to non-coding regions are also discussed.

    • István Bartha
    • , Julia di Iulio
    • , J. Craig Venter
    •  & Amalio Telenti
  • Review |

    Sexual conflict is thought to increase population genetic diversity though balancing selection, which has important evolutionary implications. This Review discusses how population genomic approaches are contributing to a deeper understanding of sexual conflict and how it is resolved.

    • Judith E. Mank

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