Red human organs on a grey chip that connects them through channels on a blue background

Human organs-on-chips for disease modelling, drug development and personalized medicine

This Review summarizes how human organ chip systems have been used to model complex diseases and rare genetic disorders

  • Donald E. Ingber
Review Article

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  • A paper in Nature Genetics identifies a mechanism involving the transcription factor DUXBL that controls the development of early embryonic mouse cells past stages marked by totipotency.

    • Henry Ertl
    Research Highlight
  • In this Tools of the Trade article, Dongsheng Bai and Chenxu Zhu describe SIMPLE-seq, a scalable single-cell sequencing method that simultaneously decodes the cytosine modifications 5mC and 5hmC.

    • Dongsheng Bai
    • Chenxu Zhu
    Tools of the Trade
  • A paper in Nature reports a ‘Z-DNA-anchored’ model for the target specificity of the transcription factor AIRE, involving promoter poising at double-strand breaks.

    • Kirsty Minton
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  • Reflecting on the importance of short tandem repeats (STRs) in population genetics, Ning Xie highlights a 2023 publication that characterized genome-wide STR variation in global human genomes to expand our understanding of STR genetic diversity within and across populations.

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  • A publication in Nature reports the data release of around 245,000 clinical-grade whole-genome sequences as part of the NIH’s All of Us Research Programme. Several companion papers highlight the value of better capturing global genomic diversity.

    • Linda Koch
    Research Highlight
Image of part of a cancer genome circus plot

Cancer genomics

This collection showcases how cancer genomics has informed our understanding of cancer pathogenesis, unravelled potential future therapeutic targets and driven advances that are starting to translate into the clinic. This resource provides a comprehensive bench-to-bedside overview of cancer genomics, which will be useful to researchers and clinicians alike.
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