Guojie Zhang discusses a seminal paper by Alfred H. Sturtevant, in which he concluded based on his observations in fruitflies that the mutation rate is an evolving parameter.

In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that was found exclusively in Indigenous populations from the Americas. She describes how this work served as inspiration for the inclusion of more diverse populations in the 1000 Genomes Project.

Steiner highlights a study by Protacio et al., which has identified molecular mechanisms underlying the plasticity of meiotic recombination in Schizosaccharomyces pombe.

In this Journal Club, Morgan Levine discusses a publication by Rose and Charlesworth that provided direct evidence of the impact of natural selection on differential ageing rates.

A new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with potential roles in protecting from infection by other retroviruses.

A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.

A new study in Science reports the refactoring of genetic codes in Escherichia coli to create a bidirectional ‘genetic firewall’ that prevents genetic transfer from or to synthetic organisms.

A new study reports Epigenomic MERFISH, an imaging method that combines CUT&Tag and MERFISH to interrogate histone marks representing cis-regulatory elements in single cells while preserving spatial information.

A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the regulatory conflict that arises when a new gene incorporates into an ancestral TAD.