Species and communities can respond to global climate change by genetically adapting to new environmental conditions, by shifting their range or through phenotypic plasticity. This Review summarizes approaches that apply and integrate omics tools to experimentally investigate, monitor and predict these species responses.

In this Perspective, Carolyn Hogg discusses the utility of genomic data to conservation and the importance of adopting a translational mindset to ensure that genomics is used to its full potential to protect Earths’ declining biodiversity.

Four papers in Nature describe how ancient European migration patterns have shaped the modern human genome.

Shinichi Morishita recalls a seminal publication by Weber and Myers, who in 1997 proposed a direct whole-genome shotgun sequencing approach to tackle the human genome.

The Farm Animal GTEx project introduces a new resource for pigs, in which they map genetic variation to differences in gene expression across thousands of samples.

A study in Nature Biotechnology reports a platform that combines lentivirus capabilities with antibody recognition for targeted cell delivery and genome editing.

Kylie R. James discusses a paper by Moor et al. that described a transcriptional gradient along the intestinal axis using single-cell RNA sequencing.

Beer et al. use multiple complementary approaches to show that declining densities of the Tasmanian devil have had evolutionary effects on gene flow and selection in the subordinate predator, the spotted-tail quoll.