This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.

This image illustrates the human pancreatic microenvironment in type 2 diabetes mellitus. The pancreatic lobule, which was labelled for CD31 (vasculature) and glucagon (islet), was imaged by deep-tissue confocal microscopy with optical clearing (refractive index: 1.52) to illustrate the fatty infiltration (transmitted light signals) around the endocrine and exocrine pancreas. Image supplied by Shiue-Cheng Tang and Shih-Jung Peng at Department of Medical Science, National Tsing Hua University, Taiwan, and Luc Baeyens and Michael German at Diabetes Center, UCSF, USA.