The collection consists of Reviews and Research articles from several Nature journals, describing the latest advances in fibrosis research in various organs, including the liver, kidney, heart, skin and lung.

The past 10 years has seen great advances in the understanding and treatment of human disease. For expert perspectives on the most important breakthroughs, don't miss the FREE A Decade in Medicine eBook. In this special collection of 47 articles, leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields.

In November 2015, Nature Reviews Endocrinology(originally published asNature Clinical Practice Endocrinology & Metabolism) celebrates 10 years since the launch of the journal. To mark this occasion, we present a special Anniversary issue. These specially commissioned articles written by members of our international Advisory Board summarize the major advances in endocrinology over the past 10 years alongside predictions for the future. A special infographic provides a snapshot of 10 years of the journal in numbers.

Noncoding RNAs have important roles in the development and regulation of the endocrine system. Dysregulation of noncoding RNAs, in particular microRNAs, is associated with endocrine dysfunction. This Nature Reviews Endocrinologyweb collection on noncoding RNAs in endocrinology provides an overview of the role of these molecules in the pathogenesis of endocrine disorders such as adrenal and thyroid cancers and diabetes mellitus, as well as in normal physiological processes, such as bone growth, pregnancy and labour. The selected articles highlight current and future applications of noncoding RNAs as diagnostic and prognostic biomarkers and as therapeutic targets for personalized management of patients with a wide range of endocrine diseases.

In the developed world, birth rates are plummeting and, increasingly, individuals are delaying reproduction. At the same time, rising rates of obesity and cancer are affecting fertility (both by virtue of the disease burden and the effects of treatment). A number of factors have been shown to affect fertility in men and women, including oxidative stress, hormonal and metabolic dysfunction and physical deformity. This joint Nature Reviews UrologyandNature Reviews Endocrinologycollection on fertility and reproduction contains Reviews and commentaries written by key opinion leaders on a range of topics pertinent to the subject, from the molecular mechanisms regulating fertility and reproduction to the preservation of fertility and treatment of infertility in both men and women.

Disorders of sex development (DSDs) are congenital conditions characterized by atypical development of chromosomal, gonadal or anatomical sex. New technologies are rapidly generating vast amounts of new data on the pathogenesis of DSDs. However, the diagnosis and management of patients with DSDs remains challenging. This Nature Reviews Endocrinology collection on DSDs includes articles from leading experts in the field, covering topics from pathogenesis and management to the transition from paediatric care to adult care.

This Focus issue includes specially commissioned articles that provide an overview of the different uses of growth hormone (GH) therapy, including the treatment of children with idiopathic short stature and adult GH deficiency, as well as insights into the diagnosis and management of these disorders. Additional topics covered include the effects of altered GH signalling on obesity and lifespan, and the risks and benefits of off-label use of recombinant human GH to treat obesity and as an antiageing therapeutic.

This Focus issue includes five specially commissioned articles that provide an overview of the diagnosis and management of different endocrine disorders that affect an ageing population, and discuss the risks and benefits of certain treatment options. The topics covered include advances in our understanding of thyroid dysfunction in the elderly, the benefits and risks of postmenopausal hormone therapy, changes in pituitary function in the elderly, the interplay between oxidative stress and the endocrine system, and new therapeutic strategies against cognitive decline in ageing women.

Obesity is a major public health problem for which there are few approved medical therapies. Considerable interest exists in the outcome of new drug trials, understanding the mechanisms of obesity and the search for new potential therapeutic targets. Bariatric surgery is a popular obesity therapy and several procedures exist, including gastric bypass, gastric banding and sleeve gastrectomy. Additional approaches, such as adipose tissue transplantation and stem-cell therapy, have also been explored. This article collection from Nature Reviews EndocrinologyandNature Reviews Gastroenterology & Hepatologyprovides a comprehensive overview of the plethora of current and future approaches to treating obesity.

This Focus issue on endocrine disorders in pregnancy includes specially commissioned articles that outline the pathophysiology of different endocrine disorders that affect pregnancy and offspring outcomes and discuss optimal clinical management strategies. The topics covered were identified by leaders in the field as important areas in research and clinical practice.

Type 2 diabetes mellitus is a global epidemic. Patients with this chronic disease—which they typically have for 20–40 years—have an increased risk of cardiovascular events. During the past few years, advances in drug development and the completion of several large-scale, randomized controlled trials have helped to provide strategies to reduce the risk of cardiovascular events in this group of patients. This collection of articles from Nature Reviews CardiologyandNature Reviews Endocrinologyprovides a state-of-the-art overview of current management strategies to reduce the risk of cardiovascular events in patients with type 2 diabetes mellitus and will be a welcome resource to researchers and clinicians alike.

Hypertension is a major, worldwide health problem owing to its high prevalence and association with increased morbidity and mortality. This collection of articles from Nature Reviews Cardiology,Nature Reviews NephrologyandNature Reviews Endocrinologycomprises a selection of 11 Reviews that discuss advances in our understanding of the mechanisms of hypertension and of the assessment, management and consequences of prehypertension and hypertension, as well as future directions for prevention and treatment.