Review Articles

Filter By:

  • Two maternal cardiometabolic disorders, hypertensive disorders in pregnancy (HDP) and gestational diabetes mellitus (GDM), affect many pregnant individuals worldwide. This Review discusses the global disease burden and risk factors for HDP and GDM and discusses public health interventions that might help reduce the associated mortality and morbidity.

    • Li Jiang
    • Kun Tang
    • Zulfiqar A. Bhutta
    Review Article
  • Organoids are a promising tool for modelling diseases in vitro. This Review discusses the progress in developing liver and adipose tissue organoids to study metabolic diseases such as obesity and non-alcoholic fatty liver disease and assesses the strengths and limitations of these systems.

    • Wenxiang Hu
    • Mitchell A. Lazar
    Review Article
  • Endometrial diseases affect many women yet often have unclear pathogenesis and no definitive treatment. This Review assesses the current systems for modelling endometrial diseases in vitro and outlines future directions for these model systems.

    • Alina R. Murphy
    • Hannes Campo
    • J. Julie Kim
    Review Article
  • This Review discusses how redefining the primary aldosteronism syndrome as a multidimensional spectrum will affect the approach to the diagnosis and subtyping of primary aldosteronism.

    • Adina F. Turcu
    • Jun Yang
    • Anand Vaidya
    Review Article
  • Patients with obesity-associated metabolic dysfunction exhibit dysregulation in iron homeostasis and alterations in gut microbiota composition and functionality. This Review discusses the bidirectional relationships between the host and the microbiota in the acquisition of elemental iron and the implications for glucose metabolism.

    • Jordi Mayneris-Perxachs
    • José María Moreno-Navarrete
    • José Manuel Fernández-Real
    Review Article
  • Rare monogenic obesity is caused by pathogenic variants in single genes, while common obesity mostly has a polygenic basis. This Review discusses genetic obesity traits, the emergence of novel pharmacological treatment options that target the central melanocortin pathway and future innovative therapies.

    • Anke Hinney
    • Antje Körner
    • Pamela Fischer-Posovszky
    Review Article
  • Menopause can increase the risk of diabetes mellitus, while existing diabetes mellitus can cause early menopause. This Review discusses the interaction of diabetes mellitus and the menopause, including therapeutic management strategies for both conditions.

    • Irene Lambrinoudaki
    • Stavroula A. Paschou
    • Dimitrios G. Goulis
    Review Article
  • The actions of growth hormone (GH) on growth and many other processes are well-described. This Review highlights clinical data from patients with acromegaly or GH deficiency, alongside data from cellular and animal studies, to reveal novel actions of GH in fibrosis, cardiovascular function and cancer.

    • John J. Kopchick
    • Reetobrata Basu
    • Vishwajeet Puri
    Review Article
  • This article discusses X chromosome agents of sexual differentiation. These agents could explain some of the sex differences in incidence and severity of particular diseases.

    • Arthur P. Arnold
    Review Article
  • This article discusses evidence for the emergence of a different set of complications associated with diabetes mellitus from the traditional ones, outlines the risks and burden of these associated complications and considers implications for the future management of diabetes mellitus.

    • Dunya Tomic
    • Jonathan E. Shaw
    • Dianna J. Magliano
    Review Article
  • This Review highlights evidence that persistent enterovirus infections, particularly coxsackievirus B, trigger and/or accelerate islet autoimmunity in susceptible individuals, thereby leading to type 1 diabetes mellitus (T1DM). The potential for vaccination or antiviral therapies to prevent T1DM onset is also considered.

    • Magloire Pandoua Nekoua
    • Enagnon Kazali Alidjinou
    • Didier Hober
    Review Article
  • Menopause affects roughly half of the global population, yet many affected people do not receive the treatment they need. This Review discusses currently available menopausal hormonal therapies and novel pharmaceutical alternatives to manage menopausal symptoms.

    • Susan R. Davis
    • Rodney J. Baber
    Review Article
  • This Review considers the principal regulators of the processes of biomineralization and crystallization in human physiology. In addition, disorders of biomineralization are discussed, including bone disorders and disorders of extraskeletal mineralization.

    • Michael T. Collins
    • Gemma Marcucci
    • Rajesh V. Thakker
    Review Article
  • Macrophages in the liver can undergo phenotypic changes during metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). This Review discusses our current understanding of the changes in the proportions and functions of liver macrophage populations in health and NAFLD.

    • Emelie Barreby
    • Ping Chen
    • Myriam Aouadi
    Review Article