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  • The skeletal muscle clock directs a circadian programme of gene expression that is fundamental to both skeletal muscle and systemic energy metabolism. Notably, exercise timing can influence the skeletal muscle clock, which provides a rationale for exploring its potential role as a chronotherapeutic strategy.

    • Ryan A. Martin
    • Mark R. Viggars
    • Karyn A. Esser
    Review Article
  • The dorsal raphe nucleus (DRN) is emerging as a key regulator of food intake and energy expenditure but the molecular and functional heterogeneity of DRN neurons is largely unknown. A new study characterizes the role of glutamatergic DRN neurons in the control of food intake and identifies a pharmacological approach to target these neurons in obesity.

    • Anthony Tsang
    • Clemence Blouet
    News & Views
  • Organoid systems have great potential to improve the study of diseases such as diabetes mellitus. This Review assesses the progress in developing pancreatic organoids and bioengineered systems for modelling diabetes mellitus and its complications.

    • Belin Selcen Beydag-Tasöz
    • Siham Yennek
    • Anne Grapin-Botton
    Review Article
  • This Review outlines evidence that the gut microbiota is involved in regulating body weight homeostasis. In addition, the opportunities, limitations and challenges of using gut microbiota-related approaches as a means to achieve and maintain a healthy body weight in people with overweight or obesity are discussed.

    • Matthias Van Hul
    • Patrice D. Cani
    Review Article
  • In May 2022, the WHO released global targets for diabetes mellitus. In this Viewpoint, experts from around the world discuss the challenges and opportunities in applying these targets.

    • Alice Y. Y. Cheng
    • Marília Brito Gomes
    • Jonathan E. Shaw
    Viewpoint
  • “Adults have really boring ideas” is what we repeatedly learn from our participatory research with young people. Nevertheless, it is common practice that adults design research, questionnaires and interventions for young people. Not surprisingly, many research initiatives, questionnaires and interventions are utterly boring and a bad fit for the intended population. Consequently, many research efforts go to waste.

    • Mai J. M. Chinapaw
    • Teatske M. Altenburg
    Comment
  • A considerable proportion of autoantibody-negative children with type 1 diabetes mellitus actually have monogenic forms of diabetes mellitus, which enables tailored treatment. Thus, a diagnosis of monogenic diabetes mellitus should be considered and genetically tested for in this group of patients, even if the clinical criteria for monogenic diabetes mellitus are not met.

    • Stepanka Pruhova
    • Petra Dusatkova
    News & Views
  • Food odour recognition is involved in the food anticipatory response. A study in Nature Metabolism describes how the olfactory system differentially regulates metabolic adaptations depending on energy availability. These effects are mediated by a brain circuit involving the melanocortin system that controls systemic lipid utilization via the sympathetic nervous system.

    • Vincent Prevot
    • Ruben Nogueiras
    News & Views
  • Understanding of intermuscular adipose tissue has expanded over the past few years. This Review discusses the specific role of intermuscular adipose tissue in metabolic diseases in humans and in animal models, with a particular emphasis on the quantity and biological properties of this unique adipose tissue.

    • Bret H. Goodpaster
    • Bryan C. Bergman
    • Lauren M. Sparks
    Review Article
  • The year 2022 has been notable for game-changing early progress in clinical trials with stem cell islets; durable and promising 20-year data with long-term outcomes in clinical islet transplantation; and the development of locally protective or gene-editing-based approaches to avoid long-term immunosuppression.

    • A. M. James Shapiro
    • Kevin Verhoeff
    Year in Review
  • Calorie restriction and timed dietary intake are two approaches known to increase lifespan or delay age-associated diseases. New studies reveal the importance of the ‘how much’ and ‘when’ of dietary intake in ageing modulation and collectively demonstrate how protection of the internal clock by diet can delay the ageing process.

    • Kristin Eckel-Mahan
    Year in Review
  • Adipose tissue is highly versatile, dynamic and essential for metabolic health. In 2022, several exciting discoveries provided a high-resolution view of cellular composition and cell–cell communication within the adipose niche, and revealed how adipose tissue communicates with other organs and modulates metabolism during normal and pathophysiological states.

    • Yu-Hua Tseng
    Year in Review
  • In 2022, the activation mechanism of TSH receptor (TSHR) by TSH and autoantibodies was demonstrated, monocarboxylate transporter 8 (MCT8) deficiency was corrected with gene therapy in mice and mutant thyroid hormone receptor α (TRα) was activated with a synthetic ligand. These results offer translational perspectives for patients with common and rare diseases affecting these proteins.

    • Lars C. Moeller
    Year in Review
  • Glucagon-like peptide 1 (GLP1) analogues are licensed options for obesity, but new treatments are required to obtain better weight loss and to directly address other co-morbidities, such as non-alcoholic fatty liver disease. Research published in 2022 shows that co-agonist combinations of GLP1 with other hormones provide clinically important advances.

    • Tricia M.-M. Tan
    Year in Review