Jennie Vallis

The endocrine function of adipose tissues in health and cardiometabolic disease

This Review discusses the metabolic functions of adipose tissue-derived endocrine hormones and highlights how these factors might contribute to cardiometabolic diseases.

Latest Reviews

  • Review Article |

    Metformin is the first-line drug for treatment of type 2 diabetes mellitus (T2DM) and is effective in decreasing plasma glucose levels. This review summarizes the glucoregulatory mechanisms of metformin in T2DM and highlights emerging evidence that metformin decreases obesity-induced meta-inflammation and acts in the gastrointestinal tract.

    • Marc Foretz
    • , Bruno Guigas
    •  & Benoit Viollet
  • Review Article |

    Daily TSH secretion profiles are disrupted in some patients with hypothyroidism and hyperthyroidism. Here, the authors discuss the interconnection between circadian clocks and thyroid function and highlight the possible link between thyroid cancer and disrupted circadian machinery

    • Keisuke Ikegami
    • , Samuel Refetoff
    • , Eve Van Cauter
    •  & Takashi Yoshimura
  • Perspective |

    The COST programme funded two European Actions for the systematic elucidation of differences of sex development and congenital hypogonadotropic hypogonadism. In this Perspective article, the authors describe the achievements of these two related COST Actions and highlight the gaps in research.

    • Olaf Hiort
    • , Martine Cools
    • , Alexander Springer
    • , Ken McElreavey
    • , Andy Greenfield
    • , Stefan A. Wudy
    • , Alexandra Kulle
    • , S. Faisal Ahmed
    • , Arianne Dessens
    • , Antonio Balsamo
    • , Mohamad Maghnie
    • , Marco Bonomi
    • , Mehul Dattani
    • , Luca Persani
    •  & Laura Audi
  • Review Article |

    Adipocytes respond to environmental cues, such as metabolic stress, by releasing endocrine factors that modulate diverse physiological processes. This Review discusses the metabolic functions of adipose tissue-derived endocrine hormones and highlights how these factors might contribute to cardiometabolic diseases.

    • Ludger Scheja
    •  & Joerg Heeren
  • Review Article |

    Obesity among children and adolescents is highly prevalent in both developed and developing countries. This Review discusses data on the early determinants of childhood obesity in order to provide relevant strategies for daily clinical work.

    • Elvira Larqué
    • , Idoia Labayen
    • , Carl-Erik Flodmark
    • , Inge Lissau
    • , Sarah Czernin
    • , Luis A. Moreno
    • , Angelo Pietrobelli
    •  & Kurt Widhalm
  • Review Article |

    The human stress response has evolved to maintain homeostasis under conditions of stress. This Review outlines the role of the hypothalamic–pituitary–adrenal axis in synchronizing the stress response with circadian regulatory processes and maintaining homeostasis.

    • Georgina Russell
    •  & Stafford Lightman

News & Comment

  • News & Views |

    A large registry-based study found that maternal overweight and obesity are associated with incident type 2 diabetes mellitus in offspring. The results align with those of prospective cohort studies and emphasize a need for interventions that target maternal weight during very early gestation, to optimize maternal and offspring health.

    • Wei Perng
    •  & Emily Oken
  • Comment |

    Emerging evidence demonstrates that an increasing number of novel medications have considerable potential to induce adrenal insufficiency. This condition might lead to acute adrenocortical insufficiency, which is potentially fatal; however, the condition could be avoided if clinicians are more aware of the new findings and their implications.

    • Stefan R. Bornstein
    • , Tobias D. Bornstein
    •  & Cynthia L. Andoniadou
  • News & Views |

    Faecal microbiota transplantation (FMT) has been suggested to be a therapeutic strategy for inflammatory diseases and it is known that regular physical activity can alter the composition of the gut microbiota. Now, a study proposes that FMT might increase exercise performance in athletes, raising the possibility of ‘faecal doping’.

    • Sarah M. Turpin-Nolan
    • , Michael J. Joyner
    •  & Mark A. Febbraio


Key Advances in Endocrinology

The Key Advances in Endocrinology collection offers expert insight into the most important discoveries made each year, and is an essential resource for students, physicians and clinical researchers.

Conor A. Bradley

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