A cluster of different types of receptors connected by arcs of dotted lines, against a dark blue background.

Targeting the incretin system in obesity and type 2 diabetes mellitus

This article reviews advances in incretin-based pharmacotherapy for obesity and type 2 diabetes mellitus.

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  • An insulin molecule in purple, on a black background

    To mark the centenary of insulin's discovery, Nature Milestones presents a timeline of the past 100 years of diabetes research.

  • A human body with key endocrine structures highlighted.

    The Key Advances in Endocrinology collection offers a unique series of specially commissioned ‘Year in Review’ articles that highlight the key discoveries made each year. In these articles, leading experts describe their key advances of the year, outlining their clinical impact and implications for research.

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Islet biology

The endocrine pancreas is composed of clusters of cells, or islets, which secrete endocrine factors important for systemic metabolism, including insulin and glucagon.
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