Jennie Vallis

Circadian clocks and insulin resistance

This Review oulines the physiological links between circadian clocks and insulin sensitivity and presents current evidence for a relationship between circadian disruption and insulin resistance.

Latest Reviews

  • Review Article |

    Exercise is used to prevent and treat metabolic diseases. Finding the optimum time for exercise is important as skeletal muscle has many clock-controlled genes. This Review summarizes the current literature regarding the consequence of exercise at different times of the day.

    • Brendan M. Gabriel
    •  & Juleen R. Zierath
  • Review Article |

    In obesity management, the prevention of weight regain after weight loss is a major challenge. In this Review, the authors discuss mechanisms associated with adipose tissue that are connected to weight regain, including cellular stress, extracellular matrix remodelling and inflammation.

    • Marleen A. van Baak
    •  & Edwin C. M. Mariman
  • Review Article |

    Insulin resistance is a main determinant in the development of type 2 diabetes mellitus. Here, the authors review the physiological links between circadian clocks and insulin sensitivity and present current evidence for a relationship between circadian disruption and insulin resistance.

    • Dirk Jan Stenvers
    • , Frank A. J. L. Scheer
    • , Patrick Schrauwen
    • , Susanne E. la Fleur
    •  & Andries Kalsbeek
  • Review Article |

    Type 2 diabetes mellitus and obesity are major public health challenges; emerging evidence suggests that melatonin is involved in the development of these disorders, opening new avenues for research. This Review discusses the effect of melatonin and its receptors on glucose homeostasis, obesity and type 2 diabetes mellitus.

    • Angeliki Karamitri
    •  & Ralf Jockers
  • Review Article |

    Loss or dysfunction of β-cells is a characteristic of insulin-dependent diabetes mellitus. Regeneration of β-cells might stop or reverse the progression of the disease. This Review discusses the different modelling systems and technologies currently used to study β-cell biology in health and disease.

    • Mostafa Bakhti
    • , Anika Böttcher
    •  & Heiko Lickert

News & Comment

  • News & Views |

    The recently released physical activity guidelines for Americans advise that adults should do at least 150–300 minutes of moderate intensity aerobic physical activity per week. The scientific evidence clearly shows benefits of physical activity for a wide variety of health outcomes. However, are these guidelines also sufficient to prevent unhealthy weight gain?

    • Ulf Ekelund
    •  & I-Min Lee
  • Year in Review |

    A key component in the development from fatty liver to hepatocellular carcinoma (HCC) is the appearance of nonalcoholic steatohepatitis (NASH). The precise cellular processes that trigger the advancement of NASH towards HCC are not well understood. In 2018, three key papers were published that help us better understand these processes.

    • Saskia Reibe
    •  & Mark A. Febbraio
  • News & Views |

    Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy are currently the most popular bariatric procedures worldwide; however, there is ongoing debate regarding which is more effective. A new study involving a large multicentre cohort demonstrates significantly more weight loss with RYGB than with sleeve gastrectomy, but with almost double the rate of complications.

    • Jerry T. Dang
    •  & Shahzeer Karmali

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