Reviews & Analysis

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  • This PrimeView highlights the epidemiology of multidrug-resistant tuberculosis, and summarizes the mechanisms, diagnosis and management of this disease. It accompanies the Primer article on this topic by Dheda et al.

    PrimeView
  • Multidrug-resistant tuberculosis (MDR-TB) is caused by Mycobacterium tuberculosis that is resistant to several first-line drugs. MDR-TB is an increasing public health challenge. In this Primer, Dheda et al. summarize the epidemiology and mechanisms, and discuss diagnosis, management and quality of life of patients with MDR-TB.

    • Keertan Dheda
    • Fuad Mirzayev
    • Christoph Lange
    Primer
  • This PrimeView highlights the diagnosis of invasive candidiasis, and summarizes its epidemiology, mechanisms and management. It accompanies the Primer article on this topic by Lass- Flörl et al.

    PrimeView
  • Invasive candidiasis is a fungal disease caused by Candida pathogens. In this Primer, Lass-Flörl et al. summarize current knowledge of epidemiology and mechanisms and discuss the diagnosis, treatment and quality of life of patients with invasive candidiasis. They also highlight outstanding research questions.

    • Cornelia Lass-Flörl
    • Souha S. Kanj
    • Miriam Alisa Govrins
    Primer
  • This PrimeView highlights the mechanisms that lead to retinal detachment, and summarizes the epidemiology, diagnosis and management of this disorder. It accompanies the Primer article on this topic by Lin et al.

    PrimeView
  • Retinal detachment describes the separation of the neurosensory retina from the underlying retinal pigment epithelium, leading to impaired vision or vision loss. This Primer discusses the epidemiology, pathophysiology, diagnosis and management of this disorder and highlights future research directions.

    • Jonathan B. Lin
    • Raja Narayanan
    • Rajendra S. Apte
    Primer
  • This PrimeView highlights the pathophysiology of Alkaptonuria, a rare inherited metabolic disease, and summarizes its epidemiology, diagnosis and management. It accompanies the Primer article on this topic by Bernardini et al.

    PrimeView
  • Alkaptonuria is a rare metabolic disease that has multisystemic and debilitating effects. In this Primer, Bernardini et al. summarize current knowledge of epidemiology and mechanisms, and discuss diagnosis, management and quality of life of patients with this disorder. They also highlight outstanding research questions.

    • Giulia Bernardini
    • Daniela Braconi
    • Annalisa Santucci
    Primer
  • This Primer by Zerr et al. discusses the epidemiology, pathophysiology, diagnosis and potential future treatments for Creutzfeldt–Jakob disease and other human prion diseases.

    • Inga Zerr
    • Anna Ladogana
    • Brian S. Appleby
    Primer
  • Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that typically starts in childhood. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of ADHD.

    • Stephen V. Faraone
    • Mark A. Bellgrove
    • Jan K. Buitelaar
    Primer
  • This PrimeView highlights the pathophysiology of rotator cuff tears and accompanies the Primer article on this topic by Feeley and colleagues.

    PrimeView
  • Rotator cuff tears occur due to trauma or, most commonly, due to degenerative changes to tendon structure. This Primer summarizes the epidemiology and pathophysiology of this condition, discusses its diagnosis and management, and highlights patients’ quality of life and future research questions.

    • Asheesh Bedi
    • Julie Bishop
    • Brian T. Feeley
    Primer
  • This PrimeView highlights the epidemiology of strongyloidiasis, as well as discussing mechanisms, diagnosis, management and outlook.

    PrimeView
  • Strongyloidiasis is a helminth infection that is most common in tropical and subtropical regions. In this Primer, Gordon et al. review the global disease burden and risk factors, summarize the pathophysiology, diagnosis and prevention of this parasite infection, and provide an overview of its treatment and areas for future work.

    • Catherine A. Gordon
    • Jürg Utzinger
    • Darren J. Gray
    Primer
  • This PrimeView highlights the mechanisms of perioperative stroke, and accompanies the Primer on this topic by Fanning et al.

    PrimeView
  • Perioperative stroke — that is stroke occurring during or within 30 days of surgery — is associated with poor outcomes. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of perioperative stroke.

    • Jonathon P. Fanning
    • Bruce C. V. Campbell
    • Steven R. Messé
    Primer
  • This PrimeView highlights the pathophysiology of pulmonary hypertension, as well as discussing epidemiology, diagnosis, management and quality of life.

    PrimeView
  • Pulmonary hypertension describes a group of disorders characterized by elevated mean pulmonary artery pressure. This Primer reviews the epidemiology and pathophysiology of pulmonary hypertension, discusses diagnosis and management, and provides an overview of current open research questions.

    • Ana Mocumbi
    • Marc Humbert
    • Simon Stewart
    Primer