PrimeViews in 2018

This PrimeView accompanies the Primer on Low back pain by Vlaeyen and colleagues, and highlights the management of this condition.

This illustrated PrimeView summarizes the pathophysiology, epidemiology, diagnosis and management of autosomal dominant polycystic kidney disease (PKD) and autosomal recessive PKD.

This PrimeView accompanies the Primer by Coyle and colleagues and highlights how the optimal treatment of neonatal abstinence syndrome begins prenatally, by identifying pregnant women with opioid use or misuse and providing them with medical and social support.

This PrimeView highlights the pathophysiological mechanisms of bronchiectasis: impaired mucociliary clearance and airway obstruction can promote persistent bacterial infections and dysregulated immune responses. These mechanisms can interact and self-perpetuate, leading over time to impaired lung function.

This illustrated PrimeView provides an overview of the immunology, diagnosis and management of multiple sclerosis.

This PrimeView illustrates the mechanisms, diagnosis and management of gastroparesis; a chronic disorder defined by delayed gastric emptying, which is associated with symptoms of nausea and vomiting.

This PrimeView highlights disease mechanisms and management strategies for systemic immunoglobulin light chain amyloidosis, which is a disease characterized by the tissue accumulation of amyloid fibrillar aggregates and organ dysfunction.

An abdominal aortic aneurysm (AAA) is an abnormal enlargement of the infrarenal aorta. The pathophysiological mechanisms of AAAs lead to the weakening and thinning of the aortic wall, which can rupture and cause life-threatening haemorrhage.

This PrimeView highlights the mechanisms of immune-mediated neuropathies, a group of disorders that are caused by an immune response to peripheral nerve antigens, leading to muscle weakness, sensory deficits and other symptoms.

This illustrated PrimeView summarizes the biology, epidemiology, diagnosis and management of testicular germ cell tumours, which are the most common type of testicular cancer.

This illustrated PrimeView highlights the mechanisms of lysosomal storage disorders, a group of genetic diseases that are characterized by the accumulation of macromolecules inside lysosomes.

This illustrated PrimeView discusses the epidemiology, mechanisms, diagnosis and management of dystonia.

This illustrated PrimeView focuses on the pathophysiology of acute kidney injury-hepatorenal syndrome and also discusses the diagnosis and management of this serious disorder.

This PrimeView illustrates the pathogenetic pathways involved in Wilson disease, and discusses diagnosis and management.

REM sleep behaviour disorder (RBD) is characterized by a loss of muscle atonia during REM sleep, leading to excess muscle tone and abnormal behaviours. This PrimeView focuses on the diagnosis of RBD, which typically relies on clinical interview and video polysomnography.

This PrimeView illustrates the pathogenetic pathways involved in the development of alcoholic liver disease, and focuses on diagnosis, screening and management

Schistosomiasis is a neglected parasitic infection that is endemic in tropical countries, especially in Africa. The complex interactions between Schistosoma spp. flatworms and the human host determine the disease course.

This PrimeView focuses on the pathophysiology, diagnosis and management of cryoglobulineamia. This disorder is characterized by the presence of immunoglobulins in the blood that precipate out of solution at body temperature.

Endometriosis is a common condition in women in which tissue resembling the endometrium (the lining of the uterus) is found at sites outside the uterus, and is associated with pain and infertility.

Vibrio spp. infections include cholera (caused by Vibrio cholerae) and vibriosis (caused by non-cholera Vibrio spp.); whereas cholera is a well-known disease, vibriosis is emerging as a foodborne and wound infection, and the incidence of both diseases is expected to further increase.