Browse Articles

This PrimeView highlights the pathogenesis of hypothalamic syndrome, and summarizes the epidemiology, diagnosis and management of this disorder. It accompanies the Primer article on this topic by Müller an colleagues.

Hypothalamic syndrome is a rare disorder caused by injury to the hypothalamus from various diseases or their treatment. This Primer provides an overview of the epidemiology, pathophysiology, diagnosis and management of the syndrome, as well as the challenges in preventing hypothalamic injury and treating its sequelae.

Loneliness is associated with increased mortality and a higher risk of some cardiovascular, metabolic and neurological disorders. Co-ordinated approaches at the individual, community and society levels are needed to reduce loneliness.

This PrimeView highlights the epidemiology of atrial fibrillation and summarizes pathophysiology, diagnosis and management. It accompanies the Primer on this topic by Brundel and colleagues.

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence as populations age. This Primer provides an overview of AF epidemiology, the mechanisms underlying electropathology in AF, and the diagnostic approaches and treatments, and highlights important directions to improve understanding and management of AF in co-creation with patients.

This PrimeView highlights the prevention of tobacco and nicotine use, and accompanies the Primer article on this topic by Le Foll et al.

This Primer describes the epidemiology, mechanisms, diagnosis and management of tobacco use and tobacco use disorder. Moreover, this Primer discusses the quality of life issues associated with tobacco use and provides an overview of future research avenues for this field.

This PrimeView highlights the mechanisms of binge eating disorder, a newly classified eating disorder that is characterized by episodes of binge eating and loss of control of eating behaviour.

Binge eating disorder is an eating disorder that is characterized by loss of control of eating behaviour and episodes of eating very large amounts of food. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of binge eating disorder.

This PrimeView highlights the mechanisms of hypertensive eye disease and accompanies the Primer article on this topic by Wong et al.

Hypertensive eye disease (HED) refers to dieases of the eye that are associated with acute or chronic elevations in blood pressure. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of HED.

This PrimeView highlights the mechanisms of childhood stroke and accompanies the Primer article on childhood stroke by Wildgruber et al.

This Primer summarizes the mechanisms, epidemiology, diagnosis and treatment of stroke in children (that is, stroke occurring in those aged between 29 days and 18 years).

This PrimeView highlights the prothrombotic mechanisms associated with cancer that can lead to venous thromboembolism.

The association between cancer and a state of increased coagulability results in an elevated risk of venous thromboembolism (which includes deep vein thrombosis and pulmonary embolism), a severe co-morbidity that can lead to worsened survival.

Financial toxicity, that is, the negative effects of the economic burden of medical care, can lead to poor patient well-being and quality of life. Co-ordinated efforts by those involved in health care, supported by research into remedial approaches, are needed to ease the burden on patients.

This PrimeView highlights the mechanisms and pathophysiology of classic and exertional heatstroke and summarizes epidemiology, diagnosis and management. It accompanies the Primer on this topic by Bouchama and colleagues.

Heatstroke is a life-threatening illness typically associated with an uncontrolled rise in core body temperature and central nervous system dysfunction. This Primer describes its epidemiology, pathophysiology, diagnosis, preventive and therapeutic strategies, as well as long-term complications and areas for future research.

This PrimeView highlights the mechanisms underlying juvenile idiopathic arthritis, and summarizes the epidemiology, diagnosis and management of this disease. It accompanies the Primer on this topic by Martini and colleagues.