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  • This PrimeView highlights the pathophysiology of medication overuse headache, a secondary headache disorder caused by overuse of acute headache medications by individuals with underlying headache disorders.

    PrimeView
  • Medication overuse headache is a secondary headache disorder that occurs in those with a primary headache disorder (commonly tension-type headache or migraine). This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of medication overuse headache, and discusses how this disorder affects the quality of life of patients.

    • Sait Ashina
    • Gisela M. Terwindt
    • Richard B. Lipton
    Primer
  • This PrimeView highlights the mechanisms of ichthyosis and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Gutiérrez-Cerrajero and colleagues.

    PrimeView
  • The ichthyoses are a group of dermatological disorders characterized by generalized scaly, erythematous skin, accompanied by epidermal barrier function disruptions. This Primer by Gutiérrez-Cerrajero and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of ichthyosis, and discusses patient quality of life and open research questions for this condition.

    • Carlos Gutiérrez-Cerrajero
    • Eli Sprecher
    • Rogelio González-Sarmiento
    Primer
  • Sexual and gender minorities (SGM) experience negative attitudes, stigma, denial of care or low-quality care from health-care providers. Increased awareness and adequate training of health-care professionals and students are required to reduce biases and barriers to care for SGM people.

    • Monica Malta
    Comment
  • This PrimeView summarizes strategies for the prevention of alcohol use disorders (AUDs) and accompanies the Primer on Hazardous drinking and AUDs by MacKillop and colleagues.

    PrimeView
  • Hazardous drinking and alcohol use disorder are associated with substantial harms to both the individual and others. This Primer discusses the epidemiology, mechanisms, diagnosis and management of these disorders, and also summarizes screening, prevention and the quality of life issues faced by individuals with these disorders.

    • James MacKillop
    • Roberta Agabio
    • Jürgen Rehm
    Primer
  • This PrimeView highligths Burkitt lymphoma, an aggressive form of B cell lymphoma that can affect children and adults. Most patients with BL can be treated successfully with chemotherapy, but new therapeutic approaches are required for relapsed or refractory disease.

    PrimeView
  • Burkitt lymphoma is an aggressive form of B cell lymphoma that can affect children and adults. Its research has been central in advancing haematopathology and cancer research. This Primer by Siebert and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of this disorder, patient quality of life and open research questions.

    • Cristina López
    • Birgit Burkhardt
    • Reiner Siebert
    Primer
  • Osteosarcoma is the most common primary malignant tumour of the bone, but can also arise as a secondary tumour in individuals with a history of cancer. This PrimeView highlights the pathomechanism of these cancers.

    PrimeView
  • Osteosarcoma is the most common primary malignant tumour of the bone. This Primer by Gorlick and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of this disorder as well as the quality of life of patients and open research questions.

    • Hannah C. Beird
    • Stefan S. Bielack
    • Richard Gorlick
    Primer
  • This PrimeView highlights the pathophysiology of myelodysplastic syndromes and summarizes their epidemiology, diagnosis and management. It accompanies the Primer on this topic by Liang and colleagues.

    PrimeView
  • Myelodysplastic syndromes (MDS) are a group of blood cancers involving dysregulated haematopoiesis, which may progress to acute myeloid leukaemia. This Primer provides an overview of the epidemiology, diagnosis, pathogenesis and management of MDS.

    • Huan Li
    • Fang Hu
    • Yang Liang
    Primer
  • This PrimeView highlights the management of asplenia and spleen hypofunction and summarizes their epidemiology, diagnosis and mechanisms. It accompanies the Primer on this topic by Lenti and colleagues.

    PrimeView
  • Asplenia and hyposplenism can have multiple and complex causes and lead to morbidity and mortality, especially owing to overwhelming post-splenectomy infections. In this Primer, Lenti and colleagues review epidemiology, pathophysiology, diagnosis and management of these conditions, and discuss patient quality of life and future strategies.

    • Marco Vincenzo Lenti
    • Sarah Luu
    • Antonio Di Sabatino
    Primer
  • This PrimeView highlights the mechanisms of gallbladder cancer and summarizes its epidemiology, diagnosis and management. It accompanies the Primer on this topic by Roa and colleagues.

    PrimeView
  • Gallbladder cancer is the most common cancer of the biliary tract and often has a very poor prognosis. This Primer by Roa and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of gallbladder cancer, and discusses patient quality of life and open research questions for this disease.

    • Juan C. Roa
    • Patricia García
    • Jill Koshiol
    Primer