L. Marshall

Follicular lymphoma

Follicular lymphoma is a systemic neoplasm of the lymphoid tissue displaying germinal centre B cell differentiation. 

Latest Primers & PrimeViews

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    Motile ciliopathies are rare genetic diseases that result in defective beating of motile cilia on epithelial cells. The pathogenetic mechanisms and clinical manifestations depend on the specific mutated gene and the affected tissues. When mucociliary clearance in respiratory epithelia is impaired, the disease is called primary ciliary dyskinesia.

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  • Primer |

    Ulcerative colitis is a chronic inflammatory bowel disease affecting the rectum and the colon. This Primer describes the epidemiology, the current understanding of ulcerative colitis pathophysiology and its diagnosis. In addition, Hibi and colleagues highlight the current and emerging therapeutic strategies and discuss the most pressing questions in the field.

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  • Primer |

    The anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) are autoimmune disorders characterized by inflammation and destruction of small blood vessels. In this Primer, the authors discuss the classification of AAVs and the pathogenetic mechanisms, diagnosis and treatment of these debilitating conditions.

    • A. Richard Kitching
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  • Primer |

    Major depressive disorder is common in patients with medical diseases and accounts for a substantial part of the psychosocial burden of these diseases. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of comorbid depression in patients with medical diseases.

    • Stefan M. Gold
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  • Primer |

    Podocytopathies are kidney diseases in which podocyte injury drives proteinuria or nephrotic syndrome. This Primer discusses a shift in paradigm from patient stratification based on kidney biopsy findings towards personalized management based on clinical, morphological and genetic data.

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  • Primer |

    Hypersensitivity pneumonitis (HP) is a complex syndrome caused by the inhalation of a variety of environmental antigens in susceptible and sensitized individuals. This Primer discusses recent advances in our understanding of HP epidemiology and pathogenesis as well as the current diagnostic and therapeutic modalities.

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News & Comment

  • PrimeView |

    Motile ciliopathies are rare genetic diseases that result in defective beating of motile cilia on epithelial cells. This PrimeView highlights the epidemiology, mechanisms, diagnosis and management of motile ciliopathies, and summarizes possible future research.

  • PrimeView |

    Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the rectum and the colon. This PrimeView describes the epidemiology, pathophysiology and diagnosis of UC, and highlights the current and emerging therapeutic strategies.

  • PrimeView |

    The anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) are autoimmune disorders characterized by inflammation and destruction of small blood vessels. This PrimeView summarizes AAV epidemiology, pathophysiology, diagnosis and treatment.

  • PrimeView |

    This illustrated PrimeView accompanies the Primer article by Gold and colleagues, and highlights the mechanisms underlying comorbid depression in individuals with medical diseases.

  • PrimeView |

    Podocytopathies are kidney diseases in which injury to podocytes (key cells of the glomerulus, which is the filter in the kidney) result in proteinuria or nephrotic syndrome. This PrimeView highlights the changes in how these diseases are classified and treated.

  • PrimeView |

    This PrimeView highlights the mechanisms underlying Hypersensitivity pneumonitis, which is a syndrome caused by the inhalation of a variety of environmental antigens in susceptible and sensitized individuals.

Corrections & Correspondence

Collection

The complement system as a therapeutic target

The complement system has a key role in the innate immune system, and its dysregulation is involved in a wide range of diseases.

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