Cartoon based on the mechanisms of psoriatic arthritis

Psoriatic arthritis

Psoriatic arthritis is a complex inflammatory disease with heterogeneous clinical features, which complicates psoriasis in 30% of patients


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  • A new Comment article discusses the need for diversity in clinical trial populations to minimize outcome disparities.

    Homogeneous clinical trial populations do not accurately represent the patient populations served. Diversity in research participation is needed to minimize outcome disparities and achieve social equity.

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  • Hepatic encephalopathy is a neuropsychiatric syndrome that occurs in patients with liver disease. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of hepatic encephalopathy, and discusses how this disorder affects the quality of life of patients.

    • Dieter Häussinger
    • Radha K. Dhiman
    • Hendrik Vilstrup
  • Genetic pain loss disorders are a heterogeneous group of diseases that are characterized by reduced pain sensation. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of these disorders.

    • Annette Lischka
    • Petra Lassuthova
    • Ingo Kurth
  • Congenital diaphragmatic hernia is a rare birth defect associated with cardiopulmonary complications and high mortality and morbidity. This Primer describes the epidemiology and mechanisms of congenital diaphragmatic hernia and discusses diagnosis, management and quality of life for patients.

    • Augusto Zani
    • Wendy K. Chung
    • Richard Keijzer
  • Trachoma, caused by infection with conjunctival strains of Chlamydia trachomatis, is the most common infectious cause of blindness. This Primer summarizes the epidemiology, pathophysiology and diagnosis of trachoma as well as its management, disease control and elimination, and key areas for future research.

    • Anthony W. Solomon
    • Matthew J. Burton
    • Lamine Traoré
  • Hypothyroidism is a common condition of insufficient thyroid hormone production or metabolism, which can be life-threatening if untreated. This Primer reviews hypothyroidism epidemiology, pathogenesis, diagnosis, screening and prevention programmes, current treatment approaches, and areas for additional research.

    • Layal Chaker
    • Salman Razvi
    • Robin P. Peeters
  • Achalasia is a disorder of the oesophageal smooth muscle characterized by impaired lower oesophageal sphincter relaxation and absent or spastic oesophageal body contractions. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of achalasia, as well as patient quality of life and areas for further research.

    • Edoardo Savarino
    • Shobna Bhatia
    • C. Prakash Gyawali
  • Specific chromosomal abnormalities are associated with development of multiple myeloma and its precursor syndromes. This poster explores the process of plasma cell development, and the types and frequencies of chromosomal abnormalities and other genetic alterations that are involved in development and progression of multiple myeloma.

    • Aneta Mikulasova
    • Gareth J. Morgan
    • Brian A. Walker
  • Planetary and human health are inseparably connected; yet, health-care systems produce considerable amounts of greenhouse gas emissions, waste and pollution. A growing movement to measure and mitigate the health sector’s own climate damage is underway, supported by national policies and clinical innovation.

    • Frances Mortimer
    • David Pencheon
  • Loneliness is associated with increased mortality and a higher risk of some cardiovascular, metabolic and neurological disorders. Co-ordinated approaches at the individual, community and society levels are needed to reduce loneliness.

    • Louise C. Hawkley
  • Financial toxicity, that is, the negative effects of the economic burden of medical care, can lead to poor patient well-being and quality of life. Co-ordinated efforts by those involved in health care, supported by research into remedial approaches, are needed to ease the burden on patients.

    • Maria Pisu
    • Michelle Y. Martin
A group of women with diverse backgrounds and physiques are standing together, supporting each other and looking ahead.

Women’s health

Research into women’s health has suffered from historical neglect and lack of funding.


Nature Careers