This Primer by Cordonnier and colleagues describes the epidemiology, aetiology, pathophysiology, diagnosis and treatment of intracerebral haemorrhage.

Monogenic diabetes encompasses forms of diabetes that result from a single pathogenic genetic alteration and usually have an early onset. This Primer gives an overview of the epidemiology, pathophysiology, diagnosis and treatment of these conditions, as well as patient quality of life and open research questions.

Fetal alcohol spectrum disorders (FASD) are characterized by neurodevelopmental impairment with or without facial dysmorphology, congenital anomalies and poor growth. This Primer discusses the epidemiology, pathophysiology, diagnosis and treatment of FASD.

Pre-eclampsia is a life-threatening disease of pregnancy and a leading cause of maternal and neonatal morbidity and mortality. This Primer by Dimitriadis and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of pre-eclampsia, and discusses patient quality of life and open research questions for this condition.

Medication overuse headache is a secondary headache disorder that occurs in those with a primary headache disorder (commonly tension-type headache or migraine). This Primer reviews the epidemiology, pathophysiology, diagnosis and treatment of medication overuse headache, and discusses how this disorder affects the quality of life of patients.

The ichthyoses are a group of dermatological disorders characterized by generalized scaly, erythematous skin, accompanied by epidermal barrier function disruptions. This Primer by Gutiérrez-Cerrajero and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of ichthyosis, and discusses patient quality of life and open research questions for this condition.