Gastrointestinal pain

Gastrointestinal pain — a form of visceral pain — is common in some disorders, such as irritable bowel syndrome, Crohn’s disease and pancreatitis.


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    Topics soon to be featured in the journal include: Idiopathic inflammatory myopathies, Peritoneal surface malignancies, Endometrial cancer and Large vessel vasculitis.

  • A new Comment article discusses the need for diversity in clinical trial populations to minimize outcome disparities.

    Homogeneous clinical trial populations do not accurately represent the patient populations served. Diversity in research participation is needed to minimize outcome disparities and achieve social equity.

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  • Castleman disease includes several lymphoproliferative disorders with shared histopathological features but very different clinical presentations and course depending on the location and numbers of affected lymph nodes.

    • Antonino Carbone
    • Margaret Borok
    • Mark Bower
  • This Primer summarizes the epidemiology, diagnosis, treatment and pathophysiology of essential tremor, a movement disorder that is typically characterized by upper limb action tremor in the absence of other neurological signs.

    • Thomas Welton
    • Francisco Cardoso
    • Eng-King Tan
  • Restless legs syndrome is a common disorder that is characterized by an urge to move the legs. This Primer reviews the epidemiology, mechanisms, diagnosis and treatment of restless legs syndrome, and also summarizes the quality-of-life issues faced by patients and future research avenues.

    • Mauro Manconi
    • Diego Garcia-Borreguero
    • Yves Dauvilliers
  • Primary lymphoedema (PLE) refers to swelling of parts of the body (usually limbs) caused by anomalies in the development or functioning of the lymphatic system; PLE can result from genetic mutations and can be the only symptom or one of the manifestations of a syndrome.

    • Pascal Brouillard
    • Marlys H. Witte
    • Miikka Vikkula
  • Wilms tumour (WT) is the most common renal tumour in infants and young children. This Primer reviews the epidemiology, mechanisms, diagnosis and management of WT. In addition, the authors outline potential opportunities to translate novel biological targets to improve clinical outcomes.

    • Filippo Spreafico
    • Conrad V. Fernandez
    • Kathy Pritchard-Jones
  • Histiocytic disorders are characterized by proliferation of cells with macrophage or dendritic cell phenotype and intense inflammation. Clinical signs and symptoms depend on the specific disease and the tissues and organs affected.

    • Kenneth L. McClain
    • Camille Bigenwald
    • Carl E. Allen
  • Clinical trials often enrol homogeneous populations that do not accurately represent the patient populations served. However, diverse research participation is necessary to establish fair standards of care, minimize outcome disparities and achieve social equity. Here, the authors discuss reasons for reduced trial participation and provide a framework for increasing diversity in clinical trials.

    • Ashwarya Sharma
    • Latha Palaniappan
  • Incarcerated individuals and those with a history of incarceration have high rates of medical conditions yet face several barriers to care. Removing these barriers through adequate funding, enhancing the role of community health systems, and addressing stigma and discrimination are imperative to improve the health and well-being of this population.

    • Lisa B. Puglisi
    • Emily A. Wang
  • Vaccine hesitancy is considered a threat to global health and has been rising worldwide, particularly in resource-limited settings. This Comment discusses this issue and highlights the multiple strategies that can be implemented to address it.

    • Clarissa Simas
    • Heidi J. Larson
  • Homeless people face tremendous social and structural barriers to health care that contribute to high morbidity and mortality. Here, the authors discuss that collaborations between health systems and social services are needed to improve health and well-being in this population.

    • Michael Liu
    • Stephen W. Hwang
  • Many critically ill patients with COVID-19 are expected to face long-lasting physical, cognitive and/or mental health impairments. Here, the authors discuss the role of critical care and rehabilitation in improving recovery.

    • Megan M. Hosey
    • Dale M. Needham
Women’s health

Women’s health

Research into women’s health has suffered from historical neglect and lack of funding.

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