A schematic of the epidermis

Ichthyosis

Ichthyosis describes dermatological disorders in which the epidermal barrier function is impaired, resulting in transepidermal water loss and a lack of protection from chemical and biological insults.

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    Primers soon to be featured in the journal include Altitude illnesses, Multiple myeloma and Biliary atresia.

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  • Acute or chronic exposure to elevations above 2,500 m can lead to altitude illnesses, including acute mountain sickness, high-altitude cerebral or pulmonary oedema, and chronic mountain sickness. In this Primer, Gatterer et al. summarize the epidemiology and pathophysiology of these disorders, discuss diagnosis, prevention and treatment, and highlight areas for future research.

    • Hannes Gatterer
    • Francisco C. Villafuerte
    • Martin Burtscher
    Primer
  • Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the uncontrolled proliferation of immature lymphoid cells. In this Primer, Pagliaro et al. discuss the epidemiology, mechanisms, diagnosis and treatments of ALL.

    • Luca Pagliaro
    • Sai-Juan Chen
    • Giovanni Roti
    Primer
  • In this Primer, Ashina et al. discuss the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with trigeminal neuralgia, a chronic neuropathic facial pain disorder involving one or more branches of the trigeminal nerve that causes intense paroxysms of electric shock-like pain.

    • Sait Ashina
    • Carrie E. Robertson
    • Lars Bendtsen
    Primer
  • Carpal tunnel syndrome (CTS) is one of the most common hand conditions caused by an increased pressure on the median nerve in the carpal tunnel in the wrist. In this Primer, Dahlin et al. review the epidemiology, pathophysiology, diagnosis, management and quality of life of people with CTS; they also highlight occupational risk factors for this condition.

    • Lars B. Dahlin
    • Malin Zimmerman
    • Kevin C. Chung
    Primer
  • Paediatric hydrocephalus is the progressive distension of the cerebral ventricles in infancy or childhood. This Primer discusses the epidemiology, pathophysiology, diagnosis, screening and treatment of paediatric hydrocephalus in both high-income and low- and middle-income settings.

    • Kristopher T. Kahle
    • Petra M. Klinge
    • Jennifer M. Strahle
    Primer
  • This Primer by Weller and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of glioma in both adults and children.

    • Michael Weller
    • Patrick Y. Wen
    • Guido Reifenberger
    Primer
  • In shared decision-making, patients and clinicians work together to make care decisions. This method of care is ethically desirable and practically feasible and may be effective in making care fit: forming plans of care that maximally respond to the patient’s situation and priorities while minimally disrupting their lives.

    • Marleen Kunneman
    Comment
  • Rare diseases remain a formidable public health challenge. The key to unlocking breakthroughs in diagnosis and treatment is fostering dynamic international partnerships and streamlined data sharing. The empowerment of patient advocacy groups is essential, as they are pivotal in driving innovative research and elevating health-care standards for these often under-represented conditions.

    • Domenica Taruscio
    • William A. Gahl
    Comment
  • Conversational agents (CAs) are computer programs designed to engage in human-like conversations with users. They are increasingly used in digital health applications, for example medical history taking. CAs have potential to facilitate health-care processes when designed carefully, considering quality aspects and are integrated into health-care processes.

    • Kerstin Denecke
    Comment
  • Historically, the health-care response to natural disasters has been reactive, with responders rushing to the scene using deployable assets to treat those affected. The global community must increase efforts to complement this approach with proactive preparedness and readiness strategies designed to enhance disaster health-care capacity at a local level.

    • Gregory Ciottone
    • Flavio Salio
    Comment
  • The concept of syndemics specifies which, where and how disease concentrations and interactions emerge and persist. Recognizing multimorbidity within a population or region is fundamental to syndemics because multimorbid conditions often share upstream drivers, including social inequalities. Applying syndemics to health care can inform clinical and policy interventions.

    • Justin Dixon
    • Emily Mendenhall
    Comment
  • Refugees are a growing and dynamic global population that require theories, programmes and policies to improve community-based integration and health care. Although many gender, cultural and system barriers persist, countries must innovate to support migration flow, universal care coverage, trauma-informed approaches and health equity for refugees.

    • Kevin Pottie
    • Doug Gruner
    Comment
A group of women with diverse backgrounds and physiques are standing together, supporting each other and looking ahead.

Women’s health

Research into women’s health has suffered from historical neglect and lack of funding.
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