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Rapid advances in next-generation sequencing (NGS) are facilitating deeper insights into the molecular classifications of cancer and the mechanisms of resistance development, thereby paving the way for a new era of personalized medicine. In this Perspective, Simon and Roychowdhury explore how genomic information can be used in the design of clinical trials for molecularly targeted anticancer drugs as well as for the development of new biomarkers.
Extracellular vesicles have emerged as important mediators of intercellular communication, and they are now implicated in numerous biological and pathological processes. Here, Wood and colleagues focus on the role of extracellular vesicles in diseases including cancer, HIV and neurodegenerative disorders, and consider how extracellular vesicles might be targeted or directly exploited for therapeutic intervention.
