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Therapeutic RNA-silencing oligonucleotides in metabolic diseases

Find out about how advances in oligonucleotide design and delivery are enabling the development of antisense and siRNA-based therapeutics for metabolic diseases in this Review in the June issue

  • Algera Goga
  • Markus Stoffel
Review Article

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    Following the landmark approval of imatinib two decades ago, over 70 kinase inhibitors are transforming the treatment of cancer and other disorders. This poster highlights key advances in this period, including the increased molecular and structural understanding of kinases and strategies to combat resistance to kinase inhibitors in cancer therapy.

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