Find out about new drugs approved by the FDA in 2020

The FDA approved 53 novel drugs in 2020, the second highest count in over 20 years. For more on trends with deals and IPOs last year, see the news and comment section below.

  • Asher Mullard
News

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    • Protein lysine methylation is an important post-translational modification of histone and non-histone proteins. In this Review, Gozani and colleagues discuss the role of protein lysine methyltransferases, the ‘writers’ of protein lysine methylation, in a range of diseases, and the progress and potential of targeting these enzymes therapeutically. They also consider the biology of lysine methyltransferases beyond epigenetic regulation as emerging targets for drug discovery.

      • Kamakoti P. Bhat
      • H. Ümit Kaniskan
      • Or Gozani
      Review Article
    • Numerous proteins and lipids are covered in glycans, which affects the way these molecules interact. In this Review, Smith and Bertozzi discuss therapies targeting proteins that recognize glycosylation, namely the selectins and Siglecs, as well as glycan-targeted antibodies that have entered the clinic or are in development. They provide their perspectives on the future of glycobiology.

      • Benjamin A. H. Smith
      • Carolyn R. Bertozzi
      Review Article
    • Image-based profiling is a strategy to mine the rich information in biological images. Carpenter and colleagues discuss how the application of machine learning is renewing interest in image-based profiling for all aspects of the drug discovery process, from understanding disease mechanisms to predicting a drug’s activity or mechanism of action.

      • Srinivas Niranj Chandrasekaran
      • Hugo Ceulemans
      • Anne E. Carpenter
      Review Article
    • Examining B cell depletion therapy (BCDT), an approved treatment for B cell malignancies, in autoimmune conditions has provided key insights into basic B cell biology. In this Review, Gommerman and colleagues discuss BCDT in autoimmune conditions, highlighting diseases in which BCDT has been clinically effective and the potential and pitfalls for BCDT in autoimmune conditions in which it has not yet been efficacious.

      • Dennis S. W. Lee
      • Olga L. Rojas
      • Jennifer L. Gommerman
      Review Article
    • The Notch pathway plays multiple complex roles in cancer, exerting oncogenic or tumour-suppressive actions depending on the context. Here Miele and colleagues provide an overview of current understanding of the functions of Notch in cancer, highlighting key implications for the development of Notch-targeting therapeutics. Agents in clinical development and emerging therapeutic strategies are highlighted.

      • Samarpan Majumder
      • Judy S. Crabtree
      • Lucio Miele
      Review Article

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