Circadian rhythm as a therapeutic target

Find out how different pathways involved in the regulation of the circadian clock could be therapeutically targeted for a range of disorders in this review in the April issue.    

  • Wei Ruan
  • Xiaoyi Yuan
  • Holger K. Eltzschig
Review Article

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    • Gasdermins (GSDMs) are a recently characterized protein family that mediate a programmed inflammatory cell death termed pyroptosis. Here, Lieberman and colleagues review current understanding of the expression, activation and regulation of GSDMs, highlighting their roles in cell death, cytokine secretion and inflammation. Emerging opportunities to develop GSDM-targeted drugs and the associated challenges are highlighted.

      • Xing Liu
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      • Judy Lieberman
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