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  • Focus |

    Nature Reviews Clinical Oncologyfeatures a Focus on metastasis in the June and July 2011 issues. This focus features discussions of the recent breakthroughs in knowledge of the mechanisms and treatment of metastasis by key opinion leaders in the field. Topics include tumor self-seeding, metastasis-suppressor genes, bone metastasis, brain metastasis and oligometastases. The web page for this focus issue also includes links to related articles from across Nature Publishing Group to provide more background information on this topic.

  • Focus |

    Nature Reviews Clinical Oncologyis proud to feature a Focus on personalized medicine. The March 2011 special issue features discussions of the advances, challenges and progress in the field of personalized cancer medicine by key opinion leaders who presented at the Worldwide Innovative Networking (WIN) symposium held in Paris in July 2010. Topics include blood-based strategies to detect and monitor cancer, methodological and practical challenges, immune parameters and chemotherapy efficacy, P4 medicine, and personalized medicine perspective from a cancer center. The web page for this focus issue also includes links to related articles from across Nature Publishing Group to provide more background information on this topic.

  • Focus |

    This Focus issue on breast cancer contains specially commissioned Reviews that translate the latest pathogenesis and management insights into clinical practice. The challenges in defining and treating triple-negative tumors are highlighted. Synthetic lethality provides a novel approach to identify new targets, and advances in the treatment of BRCA mutation carriers using PARP inhibitors are described. Genetic testing for patients with BRCA mutations and the implications for incorporating such testing into mainstream cancer settings is discussed, together with the role of circulating tumor cells in metastasis development and how genetic profiling of these cells can help improve patient management.

  • Focus |

    In this Focus issue, leaders in the field provide an update on the current status of prognostic and predictive biomarkers in oncology and debate the major challenges such as statistical validation, and appropriate use and validation of surrogate endpoints. The value of CA125 monitoring in treatment decision making for ovarian cancer, the clinical development of molecular markers to individualize adjuvant therapy in colon cancer, and guidance for physicians in critically evaluating published studies on prognostic gene-expression signatures are highlighted. This Focus provides a valuable and cutting-edge resource for clinicians and researchers.

  • Series |

    Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential angiogenic targets and the development of novel antivascular agents. Many of these agents have shown promising antitumor activity. This series of articles examines the advances in our understanding of this complex process and covers topics such as vessel branching morphogenesis, small-molecule and large-molecule therapies, management of adverse effects caused by the antiangiogenic agents and biomarkers of response and resistance.