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Going deep with NIR-II light

Learn more about this and other topics in our June issue

  • Zeyu Zhang
  • Yang Du
  • Jie Tian
Review Article


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    In this Collection, you can find the latest articles published in Nature Reviews Clinical Oncology that discuss trends in cancer incidence and mortality.

  • viral particles floating

    Read all the COVID-19-related contents published in our journal, which will be freely available during the pandemic.

  • four diverse women together

    This regularly updated collection of articles published in the Nature Reviews journals provides in-depth discussions of recent research and medical advances in fields covering women’s health in the broadest sense. These health conditions can affect cisgender, transgender, intersex and/or non-binary people with female-specific organs and hormonal cycles.

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    Join Nature Reviews Immunology, Nature Immunology, Nature Medicine and Nature Cancer in a Nature Conference co-organised with the Dana Farber Cancer Institute on June 10-12 in Boston. Submit your abstract by April 12, 2024.


    • De-escalation of treatment for HER2+ breast cancer is a priority, given the increase in cure rates owing in part to improved HER2-targeted therapies. In this regard, the neoadjuvant approach provides the ideal platform to test less-intensive treatment regimens. Here we highlight a study that demonstrated the role of the metabolic response after dual HER2 blockade as a method of selecting patients who are most likely to benefit from chemotherapy-free neoadjuvant therapy.

      • Maria Vittoria Dieci
      • Valentina Guarneri
      News & Views
    • The majority of patients with cancers of unknown primary have unfavourable outcomes when they receive empirical chemotherapy. The shift towards using precision medicine-based treatment strategies involves two options: tissue-agnostic or site-specific approaches. Here, we reflect on how cytology-based deep learning tools can be leveraged in these approaches.

      • Elie Rassy
      • Nicholas Pavlidis
      News & Views
    • Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of various haematological malignancies but is associated with characteristic toxicities as well as less well-defined adverse effects, many of which can be severe and potentially fatal. The increasing clinical experience with CAR T cell products has resulted in better recognition and management of these toxicities using a range of pharmacotherapies, although this is an area of continued evolution and refinement. In this Review, Brudno and Kochenderfer discuss the current understanding and clinical management of CAR T cell-associated toxicities.

      • Jennifer N. Brudno
      • James N. Kochenderfer
      Review Article
    • Lessons from the prevention of cervical cancer, the first cancer type deemed amenable to elimination, can provide information on strategies to manage other cancers. Infection with human papillomavirus (HPV) causes virtually all cervical cancers and an important proportion of other cancer types. The authors of this Review discuss the epidemiology of HPV-associated cancers and the potential for their elimination, focusing on the cofactors that could have the greatest effect on prevention efforts and health equity.

      • Talía Malagón
      • Eduardo L. Franco
      • Salvatore Vaccarella
      Review Article
    • Following their successful implementation in the COVID-19 pandemic, the technology behind mRNA vaccines is now being applied to cancer. In this Review, the authors described the several decades of development of mRNA vaccines for patients with cancer, including initial developments in this area involving cell-based vaccines as well as more recent developments with nanoparticle-encapsulated vaccines, which are beginning to show promising clinical activity.

      • Elias J. Sayour
      • David Boczkowski
      • Smita K. Nair
      Review Article

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